Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
Reads0
Chats0
TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
Citations
More filters
Posted ContentDOI
Gut microbiome signatures of risk and prodromal markers of Parkinson's disease
Sebastian Heinzel,Velma T. E. Aho,Ulrike Suenkel,Anna-Katharina von Thaler,Claudia Schulte,Claudia Schulte,Christian Deuschle,Christian Deuschle,Lars Paulin,Sari Hantunen,Kathrin Brockmann,Kathrin Brockmann,Gerhard W. Eschweiler,Walter Maetzler,Daniela Berg,Daniela Berg,Petri Auvinen,Filip Scheperjans +17 more
TL;DR: The impact of the gut microbiome on PD risk and potential microbiome-dependent subtypes in the prodrome of PD need further investigation based on prospective clinical and (multi)omics data in incident PD cases.
Posted ContentDOI
Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men
Manuela Gries,Anne Christmann,Steven Schulte,Maximilian Weyland,Rommel S,Monika Martin,Baller M,Ralph Röth,Stefanie Schmitteckert,Marcus M. Unger,Yang Liu,Frederik Sommer,Timo Mühlhaus,Michael Schroda,Jean-Pierre Timmermans,Isabel Pintelon,Gudrun A. Rappold,Markus Britschgi,Hilal A. Lashuel,Menger,Matthias W. Laschke,Beate Niesler,Karl-Herbert Schäfer +22 more
TL;DR: It is found that the proteins neurofilament light chain, vesicle-associated membrane protein 2 and calbindin 2, together with the miRNAs that regulate them, are potential biomarkers of early PD that may facilitate timely treatment and/or prevention of PD in men.
Journal ArticleDOI
pink1, atp13a2 and uchl1 expressions are affected by inflammation in the brain.
TL;DR: The effect of inflammation, one of the major risk factors in PD on expressions of the PD-related genes, suggests that pink1, atp13a2 and uchl1 expressions are regulated by inflammation, and this regulatory mechanism might be involved in the progress of PD.
Journal ArticleDOI
The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy
Violina Kakoty,Sarathlal K C,Sunil Kumar Dubey,Chih Hao Yang,Prashant Kesharwani,Rajeev Taliyan +5 more
TL;DR: In this article, the basic components of the gut that might be responsible for aggravating lewy pathology, the mediator(s) responsible for transmission of PD pathology from gut to brain and the important role of trehalose in ameliorating gut dysbiosis related PD complications that would eventually pave the way for therapeutic management of PD.
Journal ArticleDOI
Lewy pathology of the submandibular gland in Lewy body disease: A report of autopsy cases.
Yasuhiro Sakashita,Tomoyasu Matsubara,Tadayuki Takata,Zen-ichi Tanei,Atsuko Motoda,Mikihiro Yamazaki,Ito Kawakami,Renpei Sengoku,Yuko Saito,Tomio Arai,Masahito Yamada,Shigeo Murayama +11 more
TL;DR: In this article, the submandibular gland was employed as a biopsy site for detecting Lewy pathology, and the sensitivity was 89.1% in PD and 75.4% in DLB.
References
More filters
Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
Related Papers (5)
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more