Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
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TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
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Journal ArticleDOI
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more
TL;DR: It is reported herein that gut microbiota are required for motor deficits, microglia activation, and αSyn pathology, and suggested that alterations in the human microbiome represent a risk factor for PD.
Journal ArticleDOI
Gut microbiota are related to Parkinson's disease and clinical phenotype.
Filip Scheperjans,Velma T. E. Aho,Pedro A. B. Pereira,Kaisa Koskinen,Lars Paulin,Eero Pekkonen,Elena Haapaniemi,Seppo Kaakkola,Johanna Eerola-Rautio,Marjatta Pohja,Esko Kinnunen,Kari Murros,Petri Auvinen +12 more
TL;DR: The findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype, and the suitability of the microbiome as a biomarker is warranted.
Journal ArticleDOI
Interactions between the microbiota, immune and nervous systems in health and disease
TL;DR: The role of CNS-resident and peripheral immune pathways in microbiota–gut–brain communication during health and neurological disease is discussed.
Journal ArticleDOI
Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls.
Marcus M. Unger,Jörg Spiegel,Klaus-Ulrich Dillmann,David Grundmann,Hannah Philippeit,Jan Bürmann,Klaus Faßbender,Andreas Schwiertz,Karl-Herbert Schäfer +8 more
TL;DR: This study confirms the recently reported association between PD and the abundance of certain gut microbiota and shows a reduction in fecal SCFA concentrations, which might, theoretically, induce alterations in the ENS and contribute to gastrointestinal dysmotility in PD.
References
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Journal ArticleDOI
Increased production of tumour necrosis factor-alpha interleukin-1 beta, and interleukin-6 by morphologically normal intestinal biopsies from patients with Crohn's disease.
Jean-Marie Reimund,C. Wittersheim,Dumont S,Christian D. Muller,J S Kenney,René Baumann,P. Poindron,Bernard Duclos +7 more
TL;DR: These consistently raised TNF-alpha, IL-1 beta and IL-6 secretions by normal appearing mucosa from patients with Crohn's disease provide evidence for a sustained immune stimulation in Crohn't disease even in the absence of patent inflammation.
Journal ArticleDOI
Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease?
Anne Cornet,Tor C. Savidge,Julie Cabarrocas,Wen-Lin Deng,Jean-Frederic Colombel,Hans Lassmann,Pierre Desreumaux,Roland S. Liblau +7 more
TL;DR: It is demonstrated that disruption of theEnteric glial cell network in CD patients represents another early pathological feature that may be modeled after CD8+ T cell-mediated autoimmune targeting of enteric glia in double transgenic mice.
Journal ArticleDOI
Evidence for the presence of S-100 protein in the glial component of the human enteric nervous system.
TL;DR: It is demonstrated here, using immunohistochemistry and electron immunocytochemistry, that both enteric glial cells and Schwann cells of the human gut contain densely immunoreactive S-100, and this protein can therefore be regarded as a common marker for the glial components of the enteric nervous system.
Journal ArticleDOI
Pathological lesions in colonic biopsies during Parkinson’s disease
Thibaud Lebouvier,Tanguy Chaumette,Philippe Damier,Emmanuel Coron,Yann Touchefeu,S Vrignaud,Philippe Naveilhan,J. P. Galmiche,S. Bruley des Varannes,Pascal Derkinderen,Michel Neunlist +10 more
TL;DR: Parkinson's disease (PD) is a neurodegenerative condition that affects 1% of the population over 65 years of age as discussed by the authors.The two pathological hallmarks of PD are a loss of dopaminergic neurons in the substantia nigra (SN) and the presence of cytoplasmic eosinophilic inclusions termed Lewy bodies (LBs).
Journal ArticleDOI
Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption
A C Aubé,Julie Cabarrocas,Jan Bauer,David Philippe,Philippe Aubert,Doulay F,Roland S. Liblau,J. P. Galmiche,Michel Neunlist +8 more
TL;DR: Glia disruption induces changes in the neurochemical coding of enteric neurones, which may partly be responsible for dysfunctions in intestinal motility and permeability.
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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more