Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
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TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
Citations
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GI Symptoms, Energy Balance and Nutrition Assessment in Parkinson's disease
TL;DR: The nature of problems of Parkinson’s disease as described in research literature are described, and some suggestions as to how these issues may be addressed are offered.
Journal ArticleDOI
The contribution of the peripheral immune system to neurodegeneration
Journal ArticleDOI
Metagenomics of the Gut Microbiome in Parkinson's Disease: Prodromal Changes.
Natalia Palacios,Jeremy E. Wilkinson,Kjetil Bjornevik,Michael A. Schwarzschild,Lauren J. McIver,Alberto Ascherio,Curtis Huttenhower +6 more
TL;DR: In this article , a nested case-control study within two large epidemiological cohorts was conducted to examine the role of the gut microbiome in Parkinson's disease (PD) and features suggestive of prodromal PD.
Posted ContentDOI
Interaction of an α-synuclein epitope with HLA-DRB1*15:01 initiates early enteric features of Parkinson’s disease in humanized mice
Francesca Garretti,Connor Monahan,Nicholas Sloan,Sanjid Shariar,Seonwoo Kim,Alessandro Sette,Tyler Cutforth,Ellen Kanter,Dritan Agalliu,David Sulzer +9 more
TL;DR: It is reported that an interaction between α-syn32-46 and HLA-DRB1*15:01 induces gut inflammation and CD4+ T cell-mediated loss of enteric dopaminergic neurons in the humanized mice, suggesting a critical role in the prodromal PD.
Journal ArticleDOI
The Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications
Tapan Behl,Ishnoor Kaur,Aayush Sehgal,Sukhbir Singh,Saurabh Bhatia,Ahmed Al-Harrasi,Gokhan Zengin,Adrian Bumbu,Felicia Liana Andronie-Cioara,Aurelia Cristina Nechifor,Daniela Gitea,Alexa Florina Bungau,Mirela Marioara Toma,Simona Bungau +13 more
TL;DR: The role of the kynurenine pathway (KP) and its metabolites and enzymes in Parkinson's disease was investigated in this article, where the authors detail the neurotoxic, neuroprotective, and immunomodulatory neuroactive components, alongside the upstream and downstream metabolic pathways of KP, forming a basis for a therapeutic paradigm of the disease while recognizing KP as a potential biomarker in PD, thus facilitating the development of a suitable target in PD management.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
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Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
Related Papers (5)
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more