Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
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TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
Citations
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Journal ArticleDOI
Parkinson’s Disease: Can Targeting Inflammation Be an Effective Neuroprotective Strategy?
TL;DR: Data from human PD studies indicating that brain inflammation is an early event in PD is discussed and the role of T-lymphocytes and peripheral inflammation for neurodegeneration is discussed.
Journal ArticleDOI
Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention
Valery N. Danilenko,Andrey Devyatkin,Mariya V. Marsova,Madina Shibilova,Rustem Ilyasov,Vladimir Shmyrev +5 more
Journal ArticleDOI
Gut microbiome-mediated regulation of neuroinflammation.
TL;DR: The intestinal microbiome influences neuroinflammatory disease in animal models, and recent studies have identified multiple pathways of communication between the gut and brain this article , and the potential impacts of the gut microbiome-brain axis on neuroinflammation represent exciting frontiers for further investigation.
Journal ArticleDOI
Cyclooxygenase 2 is upregulated in the gastrointestinal tract in Parkinson's disease.
Camille Pochard,Camille Pochard,Laurène Leclair-Visonneau,Laurène Leclair-Visonneau,Emmanuel Coron,Michel Neunlist,Michel Neunlist,Malvyne Rolli-Derkinderen,Malvyne Rolli-Derkinderen,Pascal Derkinderen +9 more
TL;DR: To determine if COX-2 is also upregulated in the gastrointestinal tract in Parkinson’s disease, two gastrointestinal biopsies were taken and RT-PCR and Western Blot analyses were performed as previously described.
Journal ArticleDOI
Parkinson's Disease and the Gut: Symptoms, Nutrition, and Microbiota.
TL;DR: Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, characterized by symptoms of bradykinesia, rigidity, postural instability, and tremor as mentioned in this paper.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more