Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
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TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
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Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson's disease.
TL;DR: The presence of GI symptoms may serve as an early marker of cognitive impairment in PD, and future studies should examine specific mechanisms underlying the relationship between gut-dysbiosis and cognitive impairment.
Journal ArticleDOI
The Link between Obesity, Microbiota Dysbiosis, and Neurodegenerative Pathogenesis.
TL;DR: In this paper, a review aims to highlight recent contributions made to alleviating human dysbiosis in degenerative diseases, especially for neurodegenerative pathologies based on the rising prevalence of obesity.
Journal ArticleDOI
Sodium Butyrate Exacerbates Parkinson's Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model
Chen-Meng Qiao,Meng-Fei Sun,Xue-Bing Jia,Yang Li,Bo-Ping Zhang,Li-Ping Zhao,Yun Shi,Zhi-Lan Zhou,Ying-Li Zhu,Chun Cui,Yan-Qin Shen +10 more
TL;DR: It is indicated that NaB exacerbates MPTP-induced PD by aggravating neuroinflammation and colonic inflammation independently of the NFκB/MyD88/TNF-α signaling pathway.
Journal ArticleDOI
Microbiome, Immunomodulation, and the Neuronal System.
TL;DR: Healthy intestinal commensals metabolize indigestible dietary substrates and produce short-chain fatty acids, which are bacterial metabolites that are essential for colonic health and regulating the function of the intestinal immune system.
Journal ArticleDOI
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle.
Saravana Babu Chidambaram,Saravana Babu Chidambaram,John R. Campbell,Musthafa Mohamed Essa,Musthafa Mohamed Essa,A.G. Rathipriya,Muhammed Bishir,Bipul Ray,Arehally M. Mahalakshmi,A. H. Tousif,Meena Kishore Sakharkar,Rajpal S. Kashyap,Robert P. Friedland,Tanya Monaghan +13 more
TL;DR: In this paper, a review summarizes the current understanding of the role of the gut microbiota in NDDs, and highlights a vicious cycle of gut dysbiosis, immune-mediated chronic neuroinflammation, impaired autophagy and proteinopathies, which contributes to the development of neurodegeneration in Alzheimer's disease, Parkinson disease, Huntington disease, multiple sclerosis, amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
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