Journal ArticleDOI
Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: A beneficial strategy to combat non-small cell lung cancer
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TLDR
It is shown that H1299 cells display a considerably lower sensitivity to erlotinib treatment, which can be restored by combining erlot inib with rapamycin or with imatinib, though to a lesser extent.About:
This article is published in Cancer Letters.The article was published on 2011-11-28. It has received 70 citations till now. The article focuses on the topics: Erlotinib & Erlotinib Hydrochloride.read more
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Autophagy modulation as a potential therapeutic target for diverse diseases
TL;DR: An overview of the mechanisms and regulation of autophagy, the role of this pathway in disease and strategies for therapeutic modulation is provided.
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EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance
Yongjie Wei,Zhongju Zou,Nils Becker,Matthew E. Anderson,Rhea Sumpter,Guanghua Xiao,Lisa N. Kinch,Prasad Koduru,Christhunesa S. Christudass,Robert W. Veltri,Nick V. Grishin,Michael Peyton,John D. Minna,Govind Bhagat,Beth Levine +14 more
TL;DR: The molecular basis by which the epidermal growth factor receptor (EGFR) tyrosine kinase regulates autophagy is defined, which may contribute to tumor progression and chemoresistance.
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Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer.
TL;DR: This review focuses on recent preclinical and clinical data on the efficacy of PI3K pathway inhibitors in NSCLC either as monotherapy approach or in combination with chemotherapy or with drugs that target other signaling transduction pathways.
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Therapeutic targets in cancer cell metabolism and autophagy
TL;DR: The metabolism of cancer cells is reprogrammed both by oncogene signaling and by dysregulation of metabolic enzymes, which have been shown to be crucial for the adaptation of tumor cells to changes in nutrient availability.
References
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mTOR: from growth signal integration to cancer, diabetes and ageing
TL;DR: Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt.
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Epidermal growth factor receptor mutations in lung cancer
TL;DR: 'oncogenic shock' is described as a mechanistic explanation for the apoptosis that follows the acute treatment of susceptible cells with kinase inhibitors, essential to the successful use of targeted therapies in common epithelial cancers.
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Targeting the phosphoinositide 3-kinase pathway in cancer.
TL;DR: The potential of and challenges for the development of therapeutic agents that target this pathway in cancer are discussed and the potential and challenges in understanding of the PI3K pathway are highlighted.
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A mammalian protein targeted by G1-arresting rapamycin–receptor complex
Eric J. Brown,Mark W. Albers,Tae Bum Shin,Kazuo ichikawa,Curtis Keith,William S. Lane,Stuart L. Schreiber +6 more
TL;DR: A mammalian FKBP–rapamycin-associated protein (FRAP) is isolate whose binding to structural variants of rapamycin complexed to FK BP12 correlates with the ability of these ligands to inhibit cell-cycle progression.
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Life and death partners: apoptosis, autophagy and the cross-talk between them
TL;DR: The cross-talk between apoptosis and autophagy is a key factor in the outcome of death-related pathologies such as cancer, its development and treatment, and the molecular regulators of both pathways are inter-connected.