Cross-Protection of Dengue Virus Infection against Congenital Zika Syndrome, Northeastern Brazil.
Celia Pedroso,Carlo Fischer,Marie Feldmann,Manoel Sarno,Estela Luz,Andres Moreira-Soto,Renata Cabral,Eduardo Martins Netto,Carlos Brites,Beate M. Kümmerer,Jan Felix Drexler +10 more
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TLDR
It is suggested that multitypic DENV infection may protect from, rather than enhance, development of CZS, and historical DENV genomic data refuted the hypothesis that unique genome signatures for northeastern Brazil explain the uneven dispersion of CzS cases.Abstract:
The Zika virus outbreak in Latin America resulted in congenital malformations, called congenital Zika syndrome (CZS). For unknown reasons, CZS incidence was highest in northeastern Brazil; one potential explanation is that dengue virus (DENV)-mediated immune enhancement may promote CZS development. In contrast, our analyses of historical DENV genomic data refuted the hypothesis that unique genome signatures for northeastern Brazil explain the uneven dispersion of CZS cases. To confirm our findings, we performed serotype-specific DENV neutralization tests in a case-control framework in northeastern Brazil among 29 Zika virus-seropositive mothers of neonates with CZS and 108 Zika virus-seropositive control mothers. Neutralization titers did not differ significantly between groups. In contrast, DENV seroprevalence and median number of neutralized serotypes were significantly lower among the mothers of neonates with CZS. Supported by model analyses, our results suggest that multitypic DENV infection may protect from, rather than enhance, development of CZS.read more
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Infections at the maternal-fetal interface: an overview of pathogenesis and defence.
Christina Megli,Carolyn B. Coyne +1 more
TL;DR: In this article, Megli et al. discuss how TORCH pathogens access the intra-amniotic space and overcome the placental defences that protect against microbial vertical transmission, and provide an overview of how various viral, bacterial and parasitic pathogens traverse the maternal-fetal interface and cause disease.
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Severe dengue in travellers: pathogenesis, risk and clinical management.
TL;DR: Dengue is more frequent than many other travel-related vaccine preventable diseases such as hepatitis A, hepatitis B, rabies, Japanese encephalitis, and yellow fever, indicating a need for a dengue vaccine for travellers.
Journal ArticleDOI
Risk of Zika microcephaly correlates with features of maternal antibodies.
Davide F. Robbiani,Priscilla C. Olsen,Priscilla C. Olsen,Federico Costa,Federico Costa,Qiao Wang,Thiago Y. Oliveira,Nivison Nery,Adeolu Aromolaran,Mateus Santana do Rosário,Gielson Almeida do Sacramento,Jaqueline S. Cruz,Ricardo Khouri,Elsio A. Wunder,Adriana Mattos,Bruno de Paula Freitas,Manoel Sarno,Gracinda Archanjo,Dina Daltro,Gustavo B. S Carvalho,Kleber Pimentel,Isadora Cristina de Siqueira,João R. M. de Almeida,Daniele Freitas Henriques,Juliana A Lima,Pedro Fernando da Costa Vasconcelos,Dennis Schaefer-Babajew,Stephanie A. Azzopardi,Leonia Bozzacco,Anna Gazumyan,Rubens Belfort,Ana P Alcântara,Gustavo Carvalho,Licia Moreira,Katiaci Araujo,Mitermayer G. Reis,Mitermayer G. Reis,Mitermayer G. Reis,Rebekah I. Keesler,Lark L. Coffey,Jennifer Tisoncik-Go,Michael Gale,Laksmi Rajagopal,Laksmi Rajagopal,Kristina M. Adams Waldorf,Dawn M. Dudley,Heather A. Simmons,Andres Mejia,David H. O’Connor,Rosemary J. Steinbach,Nicole N. Haese,Nicole N. Haese,Jessica L. Smith,Anne D. Lewis,Lois M. A. Colgin,Victoria H. J. Roberts,Antonio E. Frias,Antonio E. Frias,Meredith A. Kelleher,Alec J. Hirsch,Alec J. Hirsch,Daniel N. Streblow,Daniel N. Streblow,Charles M. Rice,Margaret R. MacDonald,Antônio Raimundo Pinto de Almeida,Koen K. A. Van Rompay,Koen K. A. Van Rompay,Albert I. Ko,Albert I. Ko,Michel C. Nussenzweig +70 more
TL;DR: This study shows that features of the maternal antibodies correlate with the risk of ZIKV-associated microcephaly, but not all neonates are affected.
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Preparedness for emerging epidemic threats: a Lancet Infectious Diseases Commission
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Dengue and Zika Viruses: Epidemiological History, Potential Therapies, and Promising Vaccines
TL;DR: A new drug lead, pep14-23 (WO2008/028939A1), was designed and patented and it was demonstrated that it inhibits the interaction of DENV C protein with the host lipid system, a process essential for viral replication.
References
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MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets
TL;DR: The latest version of the Molecular Evolutionary Genetics Analysis (Mega) software, which contains many sophisticated methods and tools for phylogenomics and phylomedicine, has been optimized for use on 64-bit computing systems for analyzing larger datasets.
Journal ArticleDOI
Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report.
Abstr Act,Patrícia Brasil,Jose Paulo Pereira,Claudia Raja Gabaglia,Luana Damasceno,Mayumi Duarte Wakimoto,Rita Maria Ribeiro Nogueira,Patricia Carvalho de Sequeira,André M. Siqueira,Liege Maria Abreu de Carvalho,Denise Cotrim da Cunha,Guilherme Amaral Calvet,Elizabeth de Souza Neves,Maria Elisabeth Lopes Moreira,Ana Elisa Rodrigues Baião,Paulo Roberto Nassar de Carvalho,Carla Janzen,Stephanie G. Valderramos,James D. Cherry,Ana Maria Bispo de Filippis,Karin Nielsen-Saines +20 more
TL;DR: Despite mild clinical symptoms in the mother, ZIKV infection during pregnancy is deleterious to the fetus and is associated with fetal death, fetal growth restriction, and a spectrum of central nervous system abnormalities.
Journal ArticleDOI
The Brazilian Zika virus strain causes birth defects in experimental models
Fernanda R. Cugola,Isabella Rodrigues Fernandes,Isabella Rodrigues Fernandes,Fabiele Baldino Russo,Beatriz C.G. Freitas,João Leonardo Rodrigues Mendonça Dias,Katia de Oliveira Pimenta Guimarães,Cecilia Benazzato,Nathalia Almeida,Graciela Conceição Pignatari,Sarah Romero,Carolina Manganeli Polonio,Isabela Werneck da Cunha,Carla Longo de Freitas,Wesley Nogueira Brandão,Cristiano Rossato,David G. Andrade,Daniele de Paula Faria,Alexandre T. Garcez,Carlos Alberto Buchpigel,Carla Torres Braconi,Erica A. Mendes,Amadou A. Sall,Paolo Marinho de Andrade Zanotto,Jean Pierre Schatzmann Peron,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +26 more
TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.
Journal ArticleDOI
Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians.
Cynthia A. Moore,J. Erin Staples,William B. Dobyns,André Pessoa,Camila V. Ventura,Eduardo Borges da Fonseca,Erlane Marques Ribeiro,Liana O. Ventura,Norberto Nogueira Neto,J. Fernando P. Arena,Sonja A. Rasmussen +10 more
TL;DR: It is concluded that congenital Zika syndrome is a recognizable pattern of structural anomalies and functional disabilities secondary to central and, perhaps, peripheral nervous system damage that can help determine essential follow-up and ongoing care for affected infants and children.
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