Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
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Biodegradable Zn–2Ag–0.04Mg Alloy for Bone Regeneration In Vivo
TL;DR: The Zn–Ag–0.04Mg alloy scaffold exhibits good biocompatibility and bone regeneration ability in vivo, and HE staining of the liver, kidney, and heart did not detect any abnormalities, confirmed the biosafety of the Zn-2Ag-0.
Peer ReviewDOI
Marine sources as an unexplored bone tissue reconstruction material -A review
TL;DR: In this paper , a wide range of available marine sources has been put into clinical trials, and the collagen found in the Marine sources has shown comparatively better results than that of the available synthetic alternatives.
Journal ArticleDOI
Multifunctional bone substitute using carbon dot and 3D printed calcium-deficient hydroxyapatite scaffolds for osteoclast inhibition and fluorescence imaging.
TL;DR: In this paper , a hybrid material, referred as [email protected, fabricated from alendronate-conjugated carbon dots (Alen-CDs) and calcium-deficient hydroxyapatite (CDHA, the mineral component of bones) scaffolds is offered as a novel multifunctional BSM for in vivo osteoclasts deactivation and fluorescence imaging.
Journal ArticleDOI
Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration
Marta Cristaldi,Rodolfo Mauceri,Laura Tomasello,Giuseppe Pizzolanti,Giovanni Zito,Riccardo Alessandro,Carla Giordano,Giuseppina Campisi +7 more
TL;DR: The aim of the paper is to review the potentialities of human exfoliated deciduous teeth stem cells (SHEDs and oral mucosa stem cells) in RM, with the purpose of their use as accessible source of MSCs for the future of pediatric patient.
References
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Journal ArticleDOI
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
Journal ArticleDOI
Synthetic biodegradable polymers as orthopedic devices.
John Middleton,Arthur J. Tipton +1 more
TL;DR: In this paper, the authors focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired, and an overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
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Complexity in biomaterials for tissue engineering
TL;DR: The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering, and exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.
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Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements.
TL;DR: The main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds.
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Synthetic polymer scaffolds for tissue engineering
TL;DR: This critical review explores how synthetic polymers can be utilised to meet the needs of tissue engineering applications, and how biomimetic principles can be applied to polymeric materials in order to enhance the biological response to scaffolding materials.