Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Octacalcium phosphate ceramics combined with gingiva-derived stromal cells for engineered functional bone grafts.
V.L. Zorin,Vladimir S. Komlev,Zorina Ai,Natalia V Khromova,E. V. Solovieva,Alexander Yu. Fedotov,I.I. Eremin,Pavel Kopnin +7 more
TL;DR: This study demonstrates that GMSCs and BMMSСs have a similar osteogenic capacity, and the usage of OCP ceramic granules in combination with BMMSCs/GMSCs significantly affects the osteo- and angiogenesis in bone grafts of ectopic models.
Journal ArticleDOI
Sandcastle Worm-Inspired Blood-Resistant Bone Graft Binder Using a Sticky Mussel Protein for Augmented In Vivo Bone Regeneration
TL;DR: The blood‐resistant coacervated mussel protein glue is a promising binding material for effective bone grafting and can be successfully expanded to general bone tissue engineering.
Journal ArticleDOI
Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects
TL;DR: In this paper, the authors elucidate the process-structure-property relationships in 3D implantable titanium alloy biomaterials processed by electron beam melting (EBM) that is based on the principle of additive manufacturing.
Journal ArticleDOI
Calcium and phosphate ions as simple signaling molecules with versatile osteoinductivity.
Soheila Ali Akbari Ghavimi,Brittany N. Allen,Jessica L Stromsdorfer,Jacob S. Kramer,Xiaolei Li,Bret D. Ulery +5 more
TL;DR: It is suggested that CaP-based biomaterials can be leveraged to achieve Ca2+ and Pi dose-dependent osteoinduction for bone regenerative engineering applications.
Journal ArticleDOI
Horizontal ridge augmentation using xenogenous bone graft-systematic review
Pedro Henrique de Azambuja Carvalho,Guilherme dos Santos Trento,Lucas Borin Moura,Giovanni Cunha,Marisa Aparecida Cabrini Gabrielli,Valfrido Antonio Pereira-Filho +5 more
TL;DR: Although the autogenous bone graft remains as the gold standard for alveolar reconstruction, this review suggests that xenogeneous bone graft is a feasible alternative for horizontal bone augmentation.
References
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