Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Journal ArticleDOI
Can the regenerative potential of an alkali-free bioactive glass composition be enhanced when mixed with resorbable β-TCP?
Manuel Marques Ferreira,Ana Brito,Catarina F. Marques,Luis F. Freitas,Eunice Carrilho,Ana M. Abrantes,Ana Salomé Pires,Maria J. Aguiar,Lina Carvalho,Maria Filomena Botelho,José M.F. Ferreira +10 more
TL;DR: In vivo performance of a new synthetic composite bone graft material demonstrated the superior bone regeneration ability of FastOs®BG alone, which was not further enhanced by adding β-TCP in the composition, confirming its already proven regenerative potential.
Journal Article
Effects of fluorinated porcine hydroxyapatite on lateral ridge augmentation: an experimental study in the canine mandible.
Yuanxiang Liu,Chengwu Liu,Ruoxuan Huang,Kaidi Chen,Baoxin Huang,Quan Liu,Zhuofan Chen,Zhipeng Li +7 more
TL;DR: FPHA achieved better ridge width maintenance and bone regeneration outcomes than PHA as a bone substitute in lateral ridge augmentation and showed a better Ridge width maintenance capacity than the blank control treatment.
Journal ArticleDOI
Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
TL;DR: In this paper, a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold was developed to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
Book ChapterDOI
Three Dimensional Porous Scaffolds: Mechanical and Biocompatibility Properties
TL;DR: The need to adopt intelligent structural approaches and targeted application-specific biocompatibility characterization, while fabricating mechanically stable and biologically functionalized 3D tissue equivalents is highlighted.
Dissertation
Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis
TL;DR: The findings from this dissertation may provide a scientific rationale for the development of novel therapeutic strategies in the treatment and management of bone defects.
References
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Journal ArticleDOI
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
Journal ArticleDOI
Synthetic biodegradable polymers as orthopedic devices.
John Middleton,Arthur J. Tipton +1 more
TL;DR: In this paper, the authors focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired, and an overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
Journal ArticleDOI
Complexity in biomaterials for tissue engineering
TL;DR: The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering, and exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.
Journal ArticleDOI
Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements.
TL;DR: The main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds.
Journal ArticleDOI
Synthetic polymer scaffolds for tissue engineering
TL;DR: This critical review explores how synthetic polymers can be utilised to meet the needs of tissue engineering applications, and how biomimetic principles can be applied to polymeric materials in order to enhance the biological response to scaffolding materials.