Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Journal ArticleDOI
Novel 3D-Printed Device for the Simple Preparation of Hydrogel Beads
RahmanKazi Anisur,SathiGulsan Ara,TaketaHiroaki,FarahatMahmoud,OkadaMasahiro,ToriiYasuhiro,MatsumotoTakuya +6 more
TL;DR: A simple and novel 3D-printed device that can produce hydrogel beads of different sizes by altering the stir speed or the solution flow rate and it is demonstrated that encapsulated MC3T3-E1 cells can survive and proliferate in the fabricated hydrogels when type I collagen is added to the solution.
Journal ArticleDOI
Physicochemical and osteoplastic characteristics of 3D printed bone grafts based on synthetic calcium phosphates and natural polymers
Elizaveta K. Nezhurina,P. A. Karalkin,Vladimir S. Komlev,I. K. Sviridova,V. A. Kirsanova,S. A. Akhmedova,Ya. D. Shanskiy,A. Yu. Fedotov,S. M. Barinov,N. S. Sergeeva +9 more
Journal ArticleDOI
The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects
TL;DR: A 3D bio-printing technology is recently developed to overcome the limitation in the composite reconstruction of the mandible using osteocutaneous-vascularized free flap, which has a limitation of additional surgery and a functional morbidity at the donor site as mentioned in this paper .
Book ChapterDOI
Sustainable Materials and Biorefinery Chemicals from Agriwastes
M.A. Martin-Luengo,Malcolm Yates,M. Ramos,F. Plou,J. L. Salgado,Ana Civantos,J.L. Lacomba,Gwendolen C. Reilly,C. Vervaet,E. Saez Rojo,A. M. Martinez Serrano,Miguel Angel Diaz,L. Vega Argomaniz,L. Medina Trujillo,S. Nogales,R. Lozano Pirrongell +15 more
TL;DR: In this paper, the authors present an open access chapter distributed under the terms of the Creative Commons Attribution License (CAPL) for the authors' work, which is an extension of their previous work.
Journal ArticleDOI
Bone Healing Promotion by Negatively Charged Polysterene Microspheres.
TL;DR: It is suggested that the negatively charged polystyrene microspheres may have a potential in promoting bone healing, either alone or as an adjunct to other bone graft materials, and should be further validated by large-scale studies in animal models and clinical trials.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Synthetic polymer scaffolds for tissue engineering
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