Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Journal ArticleDOI
Recent Trends in Newly Developed Plasma-Sprayed and Sintered Coatings for Implant Applications
TL;DR: A review of recent trends in plasma-sprayed and sintered coatings for implant applications can be found in this article, where the majority of these improvements are attributed to the addition of dopants.
Journal ArticleDOI
A novel accurate volumetric analysis protocol for evaluating secondary alveolar cleft reconstruction.
TL;DR: A novel protocol for precisely calculating the bone formation ratio (BF%) using computer-aided engineering is introduced, which has good reproducibility for evaluating outcome of different grafting materials for alveolar clefts.
Journal ArticleDOI
Hierarchical porous formation, collagen and mineralized collagen modification of polylactic acid to design mimicked scaffolds for maxillofacial bone surgery
TL;DR: In this article, a mixture of polylactic acid (PLA) and salt particles was used to construct a mimicked scaffold for maxillofacial bone augmentation, which showed a layer of collagen and mineralized collagen fibrils on the surface.
Dissertation
Characterisation of Dental Pulp Cells Derived from Carious Teeth
TL;DR: cockpit stromal/stem cells are comparable to hDPSCs in terms of their osteogenic potential and the inflammatory environment of cDPSC may offer a promising cell source for future mineralised tissue repair and regeneration.
Journal ArticleDOI
Effect of minor amounts of β-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of β-tricalcium phosphate cylinders
B. Le Gars Santoni,L. Niggli,Stefan Dolder,O. Loeffel,G.A. Sblendorio,Roman Heuberger,Yassine Maazouz,C. Stähli,Nicola Döbelin,Paul Bowen,Willy Hofstetter,Marc Bohner +11 more
TL;DR: Osteoclastic resorption was significantly inhibited by β-CPP fraction in a linear manner, which underlines the importance of controlling β- CPP content when assessing β-TCP biological performance.
References
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
Journal ArticleDOI
Synthetic biodegradable polymers as orthopedic devices.
John Middleton,Arthur J. Tipton +1 more
TL;DR: In this paper, the authors focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired, and an overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
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Complexity in biomaterials for tissue engineering
TL;DR: The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering, and exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.
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Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements.
TL;DR: The main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds.
Journal ArticleDOI
Synthetic polymer scaffolds for tissue engineering
TL;DR: This critical review explores how synthetic polymers can be utilised to meet the needs of tissue engineering applications, and how biomimetic principles can be applied to polymeric materials in order to enhance the biological response to scaffolding materials.