Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Journal ArticleDOI
Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
Jan Henkel,Maria A. Woodruff,Devakara R. Epari,Roland Steck,Vaida Glatt,Ian C. Dickinson,Peter F. M. Choong,Michael Schuetz,Dietmar W. Hutmacher +8 more
TL;DR: Bone Tissue Engineering has been the topic of substantial research over the past two decades as mentioned in this paper, and recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.
Journal ArticleDOI
Bone biomaterials and interactions with stem cells.
TL;DR: A comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells is presented and the promising seed stem cells for bone repair are summarized, and their interaction mechanisms are discussed in detail.
Journal ArticleDOI
Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices
Tinke Marie de Witte,Tinke Marie de Witte,Lidy E. Fratila-Apachitei,Amir A. Zadpoor,Nicholas A. Peppas +4 more
TL;DR: An analysis of scaffold-based growth factor delivery strategies found in the recent literature shows great promise, both by providing sustained release over a therapeutically relevant timeframe and the potential to sequentially deliver multiple growth factors.
Journal ArticleDOI
Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials
S. Amin Yavari,S.M. Ahmadi,R. Wauthle,Behdad Pouran,Jan Schrooten,Harrie Weinans,Harrie Weinans,Amir A. Zadpoor +7 more
TL;DR: It was observed that, in addition to static mechanical properties, the fatigue properties of the porous biomaterials are highly dependent on the type of unit cell as well as on porosity.
Journal ArticleDOI
Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering.
TL;DR: Issues related to scaffold biomaterials and manufacturing processes are discussed, and mechanobiology of bone tissue and computational models developed for simulating how bone healing occurs inside a scaffold are described.
References
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Journal ArticleDOI
Improved cell growth by bio-oss/PLA scaffolds for use as a bone substitute
Annalia Asti,Livia Visai,Rossella Dorati,Bice Conti,Enrica Saino,Sonia Sbarra,Giulia Gastaldi,Francesco Benazzo +7 more
TL;DR: The objective of this study was to investigate the surface modification of a natural bone substitute, Bio-Oss, coated with a synthetic polymer poly-D,L-lactide (PLA), in order to improve cell growth, suggesting that it could be a valuable grafting material.
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Biocompatibility of osteogenic predifferentiated human cord blood stem cells with biomaterials and the influence of the biomaterial on the process of differentiation
Christian Naujoks,Fabian Langenbach,Karin Berr,Rita Depprich,Norbert R. Kübler,Ulrich Meyer,Jörg Handschel,Gesine Kögler +7 more
TL;DR: The results provide evidence that insoluble collagenous bone matrix followed by β-tricalciumphosphate is highly suitable for bone tissue engineering regarding cell attachment and proliferation and indicates that biomaterials influence the gene expression of USSCs.
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Compatibility of Embryonic Stem Cells with Biomaterials
Jörg Handschel,Karin Berr,Rita Depprich,Christian Naujoks,Norbert R. Kübler,Ulrich Meyer,Michelle A Ommerborn,Lydia Lammers +7 more
TL;DR: The results show that insoluble collagenous bone matrix, followed by β-tricalciumphosphate, is most suitable for bone tissue engineering regarding cell proliferation, and phenotype, and gene expression analysis indicates that biomaterials do influence the gene expression of ESCs.
Journal ArticleDOI
Successful haploidentical bone marrow transplantation in Fanconi anemia
Ronit Elhasid,M. Weyl Ben Arush,Tami Katz,Y. Gan,Yael Shechter,I. Sami,S. Postovsky,Yair Reisner,Jacob M. Rowe +8 more
TL;DR: Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available.