Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Allograft and Collagen Membrane Augmentation Procedures Preserve the Bone Level around Implants after Immediate Placement and Restoration.
Roni Kolerman,Nayrouz Qahaz,Eitan Barnea,Eitan Mijiritsky,Liat Chaushu,Haim Tal,Joseph Nissan +6 more
TL;DR: The immediate replacement of a single maxillary tooth by implants combined with guided bone regeneration is a predictable treatment modality with favorable peri-implant bony response.
Journal ArticleDOI
A mild one-pot process for synthesising hydroxyapatite/biomolecule bone scaffolds for sustained and controlled antibiotic release
TL;DR: The suitability of this mild one-pot process for incorporating directly active proteins and antibiotics in a hydroxyapatite (HAp) based scaffold is underpinned as a promising simple-to-use platform for controlled local drug release and bone treatment.
Journal ArticleDOI
Aromatic thermosetting copolyester bionanocomposites as reconfigurable bone substitute materials: Interfacial interactions between reinforcement particles and polymer network
TL;DR: Hydxyapatite reinforced aromatic thermosetting copolyester matrix bionanocomposite is presented as a potential reconfigurable bone replacement material and the presence of a hydrogen-advanced covalent interfacial coupling mechanism between the HAs and ATSP matrix is revealed.
Journal ArticleDOI
Innovative methodology for developing a bone grafting composite biomaterial starting from the seashell of Rapana thomasiana
Graţiela Teodora Tihan,Viviana Sereanu,Aurelia Meghea,Georgeta Voicu,Madalina Georgiana Albu,Valentina Mitran,Anisoara Cimpean,Roxana Gabriela Zgârian +7 more
TL;DR: In this article, a hybrid biomaterial in the form of a sponge based on collagen gel, CaCO3 from recycled Rapana thomasiana seashell, and Na2HPO4·2H2O.
Journal ArticleDOI
Evaluation of the presence of VEGF, BMP2 and CBFA1 proteins in autogenous bone graft: Histometric and immunohistochemical analysis
Marcos Heidy Guskuma,Eduardo Hochuli-Vieira,Flávia Priscila Pereira,Idelmo Rangel-Garcia,Roberta Okamoto,Tetuo Okamoto,Osvaldo Magro Filho +6 more
TL;DR: It was not possible in this study in cortical bone block groups to detect the osteoinductive proteins in a significant amount during the repair process.
References
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