Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Journal ArticleDOI
Onlay-graft of 3D printed Kagome-structure PCL scaffold incorporated with rhBMP-2 based on hyaluronic acid hydrogel.
Jeong-Kui Ku,Jeong-Kui Ku,Kang-Gon Lee,Min-Soo Ghim,Young-Kyun Kim,Sang-Hyug Park,Yongdoo Park,Young-Sam Cho,Bu-Kyu Lee +8 more
TL;DR: In this article, a 3D printed Kagome-structured polycaprolactone (PCL) scaffold was evaluated for onlay-graft use in a rat calvarial onlaygraft model.
Journal ArticleDOI
Nurse’s A-Phase Material Enhance Adhesion, Growth and Differentiation of Human Bone Marrow-Derived Stromal Mesenchymal Stem Cells
Ruben Rabadan-Ros,Salvador D. Aznar-Cervantes,Patricia Mazón,Patricia Ros-Tárraga,Piedad N. De Aza,Luis Meseguer-Olmo +5 more
TL;DR: It is predicted that Nurse’s A-phase ceramic would present high biocompatibility and osteoinductive properties and would be a good candidate to be used as a biomaterial for bone tissue engineering.
Journal ArticleDOI
Treatment of Peri-Implant Defects in the Rabbit's Tibia with Adipose or Bone Marrow-Derived Mesenchymal Stems Cells
TL;DR: Both adipose-derived and bone marrow-derived MSC treatments are feasible alternatives to autogenous bone grafts in the treatment of peri-implant osseos defects when applied with a beta-tricalcium phosphate/collagen-based scaffold.
Book ChapterDOI
Graphene: An Emerging Carbon Nanomaterial for Bone Tissue Engineering
TL;DR: The key achievements made with graphenes for bone tissue engineering are presented with particular emphasis on their combination with biomaterials for bone regeneration and as coatings for biomedical implants.
Journal ArticleDOI
Spongostan™ Leads to Increased Regeneration of a Rat Calvarial Critical Size Defect Compared to NanoBone® and Actifuse.
Dirk Wähnert,Julian Koettnitz,Madlen Merten,Daniel Kronenberg,Richard Stange,Johannes F. W. Greiner,Christian Kaltschmidt,Thomas Vordemvenne,Barbara Kaltschmidt +8 more
TL;DR: In this article, the authors compared the clinically applied organic bone substitute materials NanoBone® (nanocrystalline hydroxyapatite and nanostructured silica gel; n = 5) and Actifuse (calcium phosphate with silicate substitution; n= 5) with natural collagen-based Spongostan™ (hardened pork gelatin containing formalin and lauryl alcohol), in bilateral rat critical-size defects (5 mm diameter).
References
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Journal ArticleDOI
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Journal ArticleDOI
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