Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
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Long-term results of ORIF of condylar head fractures of the mandible: A prospective 5-year follow-up study of small-fragment positional-screw osteosynthesis (SFPSO)
Andreas Kolk,Andreas Neff +1 more
TL;DR: This first long-term prospective follow-up study of ORIF after CHF based on osteosynthesis with 1.7 mm small-fragment positional screws (SFPSO) via a retroauricular transmeatal approach (RA) demonstrates that in all cases the major goals of OrIF in CHF could be fully achieved.
Journal ArticleDOI
Osteoinductivity of engineered cartilaginous templates devitalized by inducible apoptosis
Paul Bourgine,Celeste Scotti,Sebastien Pigeot,Laurent A.H. Tchang,Atanas Todorov,Ivan Martin +5 more
TL;DR: The utility of engineered ECM-based devices as off-the-shelf regenerative niches capable of recruiting and instructing resident cells toward the formation of a specific tissue is supported.
Journal ArticleDOI
Poly(α-hydroxy acid) based polymers: A review on material and degradation aspects
Kishore Ginjupalli,Gopal Venkat Shavi,Ranjith Kumar Averineni,Mahalinga K Bhat,Nayanabhirama Udupa,P. Nagaraja Upadhya +5 more
TL;DR: A review of biodegradable polymers based on lactic and glycolic acids, their biodegradation principles and behavior along with various problems encountered during their use and various methods used to overcome the shortcomings of these materials is presented in this paper.
Journal ArticleDOI
Medical devices biomaterials – A review:
TL;DR: This work aims to do a review of those that are the most commonly used biomaterials, and a more in-depth approach is presented to each of the four major types of biommaterials: metal, polymer, ceramic, and composites, where their main characteristics and preferred applications in the area of medical devices are described.
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Bone tissue engineering using polyetherketoneketone scaffolds combined with autologous mesenchymal stem cells in a sheep calvarial defect model
Carina Adamzyk,Paul Kachel,Mareike Hoss,Felix Gremse,Ali Modabber,Frank Hölzle,Rene Tolba,Sabine Neuss,Bernd Lethaus +8 more
TL;DR: Results show that the 3D PEKK scaffolds were cyto- and bio-compatible, and allowed for adherence, growth and osteogenic differentiation of human and ovine MSC, however, bone healing seemed unaffected by whether the scaffold was seeded with MSC.
References
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Synthetic polymer scaffolds for tissue engineering
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