Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
Reads0
Chats0
TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
More filters
Journal ArticleDOI
Phase Conversion of Ice‐Templated α‐Tricalcium Phosphate Scaffolds into Low‐Temperature Calcium Phosphates with Anisotropic Open Porosity
Journal ArticleDOI
Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects
Washington Macedo de Santana,Dircilei Nascimento de Sousa,Vania Maria Ferreira,Wagner R. Duarte +3 more
TL;DR: Simvastatin combined with BoneCeramic(r) induced significantly greater amounts of newly formed bone and has great potential for the healing of bone defects.
Journal ArticleDOI
Influence of Electron Beam Irradiation Doses on Bone Regeneration by Octacalcium Phosphate Collagen Composites
Fumihiko Kajii,Fumihiko Kajii,Atsushi Iwai,Hidenori Tanaka,Keiko Matsui,Tadashi Kawai,Shinji Kamakura +6 more
TL;DR: Results suggest that different electron beam irradiation doses influence bone regeneration by OCP/Col, and that vigorous bone remodelling and bone maturation were observed.
Journal ArticleDOI
A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification.
Hwan Kim,Hwan Kim,Hwan Kim,Xuechong Hong,Xuechong Hong,Young-Hyeon An,Mihn Jeong Park,Do-Gyoon Kim,Arin K. Greene,Bonnie L. Padwa,Nathaniel S. Hwang,Ruei-Zeng Lin,Ruei-Zeng Lin,Juan M. Melero-Martin,Juan M. Melero-Martin +14 more
TL;DR: In this paper, a biomimetic scaffold is developed that allows rapid and self-sustained endochondral ossification (EO), without initial hypertrophic chondrogenesis.
Journal ArticleDOI
Single-Stage Revision Anterior Cruciate Ligament Reconstruction Using Fast-Setting Bone Graft Substitutes
TL;DR: The use of fast-setting bone graft substitutes in the setting of single-stage revision anterior cruciate ligament reconstruction is described, useful in converting what would sometimes otherwise be approached using 2 stages into a single- stage procedure.
References
More filters
Journal ArticleDOI
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
Journal ArticleDOI
Synthetic biodegradable polymers as orthopedic devices.
John Middleton,Arthur J. Tipton +1 more
TL;DR: In this paper, the authors focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired, and an overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
Journal ArticleDOI
Complexity in biomaterials for tissue engineering
TL;DR: The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering, and exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.
Journal ArticleDOI
Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements.
TL;DR: The main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds.
Journal ArticleDOI
Synthetic polymer scaffolds for tissue engineering
TL;DR: This critical review explores how synthetic polymers can be utilised to meet the needs of tissue engineering applications, and how biomimetic principles can be applied to polymeric materials in order to enhance the biological response to scaffolding materials.