Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Blueprints for the Next Generation of Bioinspired and Biomimetic Mineralised Composites for Bone Regeneration
TL;DR: The purpose of this review is to spark new interest in biomineralisation and gain new insight into coccolithophores from a material science perspective, drawing on existing knowledge from taxonomists, geologists, palaeontologists and phycologists.
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Tissue reactions after simultaneous alveolar ridge augmentation with biphasic calcium phosphate and implant insertion—histological and immunohistochemical evaluation in humans
TL;DR: The histological findings of this study indicate an osteoconductive nature of the BCP applied, which is linked to an uneventful healing process in simultaneously augmented sites using BCP.
Journal ArticleDOI
Fabrication of Poly-l-lactic Acid/Dicalcium Phosphate Dihydrate Composite Scaffolds with High Mechanical Strength-Implications for Bone Tissue Engineering.
TL;DR: In this paper, a poly-lactic acid (PLLA)/dicalcium phosphate dihydrate (DCPD) composite was fabricated from indirect casting by indirect casting.
Journal ArticleDOI
Bone Augmentation and Simultaneous Implant Placement with Allogenic Bone Rings and Analysis of Its Purification Success.
TL;DR: The present data show that the application of the Bone Ring Technique using the FDBA rings allows for successful regeneration of alveolar bone with a predictable clinical outcome, functionality and esthetics.
Journal ArticleDOI
Bone Regeneration: A Novel Osteoinductive Function of Spongostan by the Interplay between Its Nano- and Microtopography.
Thomas Vordemvenne,Dirk Wähnert,Julian Koettnitz,Madlen Merten,Nadine Fokin,Andreas Becker,Björn Büker,Asaria Vogel,Daniel Kronenberg,Richard Stange,Günther Wittenberg,Johannes F. W. Greiner,Andreas Hütten,Christian Kaltschmidt,Barbara Kaltschmidt +14 more
TL;DR: The present findings emphasize the necessity of considering both micro- and nanotopographical cues to guide intramembranous ossification, and might provide an optimal cell- and growth-factor-free scaffold for bone regeneration in clinical settings.
References
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John Middleton,Arthur J. Tipton +1 more
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Synthetic polymer scaffolds for tissue engineering
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