Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
Reads0
Chats0
TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
More filters
Journal ArticleDOI
Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
Jan Henkel,Maria A. Woodruff,Devakara R. Epari,Roland Steck,Vaida Glatt,Ian C. Dickinson,Peter F. M. Choong,Michael Schuetz,Dietmar W. Hutmacher +8 more
TL;DR: Bone Tissue Engineering has been the topic of substantial research over the past two decades as mentioned in this paper, and recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.
Journal ArticleDOI
Bone biomaterials and interactions with stem cells.
TL;DR: A comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells is presented and the promising seed stem cells for bone repair are summarized, and their interaction mechanisms are discussed in detail.
Journal ArticleDOI
Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices
Tinke Marie de Witte,Tinke Marie de Witte,Lidy E. Fratila-Apachitei,Amir A. Zadpoor,Nicholas A. Peppas +4 more
TL;DR: An analysis of scaffold-based growth factor delivery strategies found in the recent literature shows great promise, both by providing sustained release over a therapeutically relevant timeframe and the potential to sequentially deliver multiple growth factors.
Journal ArticleDOI
Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials
S. Amin Yavari,S.M. Ahmadi,R. Wauthle,Behdad Pouran,Jan Schrooten,Harrie Weinans,Harrie Weinans,Amir A. Zadpoor +7 more
TL;DR: It was observed that, in addition to static mechanical properties, the fatigue properties of the porous biomaterials are highly dependent on the type of unit cell as well as on porosity.
Journal ArticleDOI
Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering.
TL;DR: Issues related to scaffold biomaterials and manufacturing processes are discussed, and mechanobiology of bone tissue and computational models developed for simulating how bone healing occurs inside a scaffold are described.
References
More filters
Journal ArticleDOI
A new biphasic osteoinductive calcium composite material with a negative Zeta potential for bone augmentation.
Ralf Smeets,Andreas Kolk,Marcus Gerressen,Oliver Driemel,Oliver Maciejewski,Benita Hermanns-Sachweh,Dieter Riediger,Jamal M. Stein +7 more
TL;DR: The BCC material was used in a bilateral sinus floor augmentation procedure and demonstrated a negative surface charge (negative Zeta potential) which was found to be favorable for bone regeneration and osseointegration of dental implants.
Journal ArticleDOI
TCP is hardly resorbed and not osteoconductive in a non-loading calvarial model
Jörg Handschel,Hans Peter Wiesmann,Udo Stratmann,Johannes Kleinheinz,Ulrich Meyer,Ulrich Joos +5 more
TL;DR: Evaluation of the biological response of calvarial bone towards TCP granules under non-loading conditions to assess the potential of TCP as a biodegredable and osteoconductive bone substitue material for the cranial vault revealed no TCP degradation even after 6 months of implantation.
Journal ArticleDOI
Coralline hydroxyapatite bone graft substitute: A review of experimental studies and biomedical applications
E Damien,P A Revell +1 more
TL;DR: The benefits of CHA as bone graft are predominantly its safety, biocompatibility and osteoconductivity so that it can be used as a substitution biomaterial for bone in many indications clinically.
Journal Article
Bone conditioning to enhance implant osseointegration: an experimental study in pigs.
Karl Andreas Schlegel,Frank Kloss,Peter Kessler,Stefan Schultze-Mosgau,Emeka Nkenke,Joerg Wiltfang +5 more
TL;DR: Overall, bone condensation and Colloss apparently influenced bone formation process from the onset, but over the entire 8-week healing period, differences in bone formation were not significant.
Journal ArticleDOI
Calcium and phosphate ion releasing composite: Effect of pH on release and mechanical properties
TL;DR: The new TTCP-whisker composite was "smart" and increased the Ca and PO(4) release dramatically when the pH was reduced from neutral to a cariogenic pH of 4, when these ions are most needed to inhibit caries.