Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Journal ArticleDOI
Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
Jan Henkel,Maria A. Woodruff,Devakara R. Epari,Roland Steck,Vaida Glatt,Ian C. Dickinson,Peter F. M. Choong,Michael Schuetz,Dietmar W. Hutmacher +8 more
TL;DR: Bone Tissue Engineering has been the topic of substantial research over the past two decades as mentioned in this paper, and recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.
Journal ArticleDOI
Bone biomaterials and interactions with stem cells.
TL;DR: A comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells is presented and the promising seed stem cells for bone repair are summarized, and their interaction mechanisms are discussed in detail.
Journal ArticleDOI
Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices
Tinke Marie de Witte,Tinke Marie de Witte,Lidy E. Fratila-Apachitei,Amir A. Zadpoor,Nicholas A. Peppas +4 more
TL;DR: An analysis of scaffold-based growth factor delivery strategies found in the recent literature shows great promise, both by providing sustained release over a therapeutically relevant timeframe and the potential to sequentially deliver multiple growth factors.
Journal ArticleDOI
Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials
S. Amin Yavari,S.M. Ahmadi,R. Wauthle,Behdad Pouran,Jan Schrooten,Harrie Weinans,Harrie Weinans,Amir A. Zadpoor +7 more
TL;DR: It was observed that, in addition to static mechanical properties, the fatigue properties of the porous biomaterials are highly dependent on the type of unit cell as well as on porosity.
Journal ArticleDOI
Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering.
TL;DR: Issues related to scaffold biomaterials and manufacturing processes are discussed, and mechanobiology of bone tissue and computational models developed for simulating how bone healing occurs inside a scaffold are described.
References
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Journal ArticleDOI
Conversion of adipogenic to osteogenic phenotype using crystalline porous biomatrices of marine origin.
Ruth Birk,Liat Abramovitch-Gottlib,Iris Margalit,Moran Aviv,Efrat Forti,Shimona Geresh,Razi Vago +6 more
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Journal ArticleDOI
Comparison of ectopic bone formation of embryonic stem cells and cord blood stem cells in vivo.
Jörg Handschel,Christian Naujoks,Fabian Langenbach,Karin Berr,Rita Depprich,Michelle A Ommerborn,Norbert R. Kübler,Matthias Brinkmann,Gesine Kögler,Ulrich Meyer +9 more
TL;DR: Cord blood stem cells in combination with ICBM-induced ectopic bone formation in vivo are stronger than ESCs and are considered as statistically significant compared to the basic value.
Journal ArticleDOI
A strategy to establish a gene-activated matrix on titanium using gene vectors protected in a polylactide coating.
Andreas Kolk,Cornelia Haczek,Christian Koch,Stephan Vogt,Martin Kullmer,Christoph Pautke,Herbert Deppe,Christian Plank,Christian Plank +8 more
TL;DR: A versatile procedure for preparing a gene-activated matrix on titanium in a manner that was consistent with the predicted dose-response and toxicity profiles found in NIH 3T3 cells is described.
Journal ArticleDOI
Tricalcium Phosphate as a Bone Graft Substitute in Trauma
TL;DR: Preliminary results demonstrate TCP's usefulness as a substitute for cancellous bone, accompanied by other advantages, including increased patient safety, lack of donor site morbidity, unlimited shelf life and reduced operating time.
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Posterolateral spinal fusion with nano-hydroxyapatite-collagen/PLA composite and autologous adipose-derived mesenchymal stem cells in a rabbit model.
Zi-Bin Tang,Jun-Kai Cao,Ning Wen,Haibin Wang,Zhong-Wen Zhang,Zhiqiang Liu,Jin Zhou,Cuimi Duan,Fuzhai Cui,Changyong Wang +9 more
TL;DR: The effectiveness of a new mineralized collagen matrix, nano‐hydroxyapatite–collagen–polylactic acid (nHAC–PLA), combined with autologous adipose‐derived mesenchymal stem cells (ADMSCs) as a graft material for posterolateral spinal fusion in a rabbit model was demonstrated.