Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
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SrO- and MgO-doped microwave sintered 3D printed tricalcium phosphate scaffolds: mechanical properties and in vivo osteogenesis in a rabbit model.
TL;DR: The presence of SrO and MgO as dopants in TCP scaffolds improves mechanical and in vivo biological performance and has the potential for early wound healing through accelerated osteogenesis and vasculogenesis.
Journal ArticleDOI
Biomaterials for Craniofacial Bone Regeneration
Greeshma Thrivikraman,Avathamsa Athirasala,Chelsea Twohig,Sunil Kumar Boda,Luiz E. Bertassoni +4 more
TL;DR: Various classes of biomaterials currently used in craniofacial reconstruction are discussed, including those used as delivery agents for sustained release of stem cells, genes, and growth factors and 3D printing and bioprinting techniques.
Journal ArticleDOI
Multi-material additive manufacturing technologies for Ti-, Mg-, and Fe-based biomaterials for bone substitution.
TL;DR: The aim of this review is to present the viable options of the state-of-the-art multi-material AM for Ti-, Mg-, and Fe-based biomaterials to be used as bone substitutes and identify the knowledge gaps.
Journal ArticleDOI
Innovative Biomaterials for Bone Regrowth.
Maria Rosa Iaquinta,Elisa Mazzoni,Marco Manfrini,Antonio D'Agostino,Lorenzo Trevisiol,Riccardo Nocini,Leonardo Trombelli,G. Barbanti-Brodano,Fernanda Martini,Mauro Tognon +9 more
TL;DR: In this review, the different aspects of tissue engineering applied to bone engineering were taken into consideration and the bone cellular biology/molecular genetics is introduced.
Journal ArticleDOI
Advances in osteobiologic materials for bone substitutes.
Anwarul Hasan,Batzaya Byambaa,Batzaya Byambaa,Mahboob Morshed,Mohammad Cheikh,Rana Abdul Shakoor,Tanvir Mustafy,Hany E. Marei +7 more
TL;DR: This review presents an overview of various types of osteobiologic materials to facilitate the formation of the functional bone tissue and healing of the bone, covering metallic, ceramic, polymeric, and cell‐based graft substitutes, as well as some biomolecular strategies including stem cells, extracellular matrices, growth factors, and gene therapies.
References
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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John Middleton,Arthur J. Tipton +1 more
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Complexity in biomaterials for tissue engineering
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Synthetic polymer scaffolds for tissue engineering
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