Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
Reads0
Chats0
TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
More filters
Journal ArticleDOI
Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
Jan Henkel,Maria A. Woodruff,Devakara R. Epari,Roland Steck,Vaida Glatt,Ian C. Dickinson,Peter F. M. Choong,Michael Schuetz,Dietmar W. Hutmacher +8 more
TL;DR: Bone Tissue Engineering has been the topic of substantial research over the past two decades as mentioned in this paper, and recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.
Journal ArticleDOI
Bone biomaterials and interactions with stem cells.
TL;DR: A comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells is presented and the promising seed stem cells for bone repair are summarized, and their interaction mechanisms are discussed in detail.
Journal ArticleDOI
Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices
Tinke Marie de Witte,Tinke Marie de Witte,Lidy E. Fratila-Apachitei,Amir A. Zadpoor,Nicholas A. Peppas +4 more
TL;DR: An analysis of scaffold-based growth factor delivery strategies found in the recent literature shows great promise, both by providing sustained release over a therapeutically relevant timeframe and the potential to sequentially deliver multiple growth factors.
Journal ArticleDOI
Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials
S. Amin Yavari,S.M. Ahmadi,R. Wauthle,Behdad Pouran,Jan Schrooten,Harrie Weinans,Harrie Weinans,Amir A. Zadpoor +7 more
TL;DR: It was observed that, in addition to static mechanical properties, the fatigue properties of the porous biomaterials are highly dependent on the type of unit cell as well as on porosity.
Journal ArticleDOI
Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering.
TL;DR: Issues related to scaffold biomaterials and manufacturing processes are discussed, and mechanobiology of bone tissue and computational models developed for simulating how bone healing occurs inside a scaffold are described.
References
More filters
Journal ArticleDOI
The use of allograft bone in lumbar spine surgery.
TL;DR: A literature review of allograft bone use in lumbar spine surgery finds that fresh-frozen grafts are stronger, more immunogenic and more completely incorporated than freeze-dried grafts.
Journal ArticleDOI
Biosynthetic bone grafting.
TL;DR: Data support the concept that although products that contain only one of the three key components of a bone graft may regenerate bone successfully, composites of theThree key components will be more successful clinically.
Journal ArticleDOI
Measurements of the solubilities and dissolution rates of several hydroxyapatites.
TL;DR: The solubility and rate of dissolution of three apatite sources, BoneSource, Norian cranial repair system (CRS), and a sintered hydroxyapatite (Calcitite) are evaluated in a thermodynamic closed system.
Journal ArticleDOI
The material science of calcium phosphate ceramics
J.F. Osborn,H. Newesely +1 more
TL;DR: High crystallinity and large material density result in resistance to dissolution and long lasting stability, and amorphous ultrastructure and porous formation enhance interface activity and bone ingrowth, but also biological degradation of the ceramic implant material.
Journal ArticleDOI
Healing of segmental bone defects with granular porous hydroxyapatite augmented with recombinant human osteogenic protein-1 or autologous bone marrow.
Frank C. den Boer,Burkhard Wippermann,T. J. Blokhuis,Peter Patka,Fred C. Bakker,H. J. T. M. Haarman +5 more
TL;DR: Healing of bone defects, treated with porous hydroxyapatite, can be enhanced by the addition of rhOP‐1 or autologous bone marrow, and the results of these composite biosynthetic grafts are equivalent to those of autograft.