Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
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Biological functionality and mechanistic contribution of extracellular matrix‐ornamented three dimensional Ti‐6Al‐4V mesh scaffolds
TL;DR: A higher cell functionality such as cell adhesion, proliferation, and growth including cell-cell and cell-material interaction were observed on dECM ornamented Ti-6Al-4V scaffolds, which were characterized by using markers for focal adhesion and cytoskeleton such as vinculin and actin.
Journal ArticleDOI
Hydrophilicity, Viscoelastic, and Physicochemical Properties Variations in Dental Bone Grafting Substitutes
Branko Trajkovski,Matthias Jaunich,Wolf-Dieter Müller,Florian Beuer,Gregory-George Zafiropoulos,Alireza Houshmand +5 more
TL;DR: A new insight is initiated into the DBGS differences and their importance for successful clinical results by investigating the dimensional changes and molecular mobility by Dynamic Mechanical Analysis of xenograft, synthetic, and allograft (maxgraft®, Puros®) blocks in a wet and dry state.
Journal ArticleDOI
Planning of mandibular reconstructions based on statistical shape models.
Stefan Raith,Sebastian Wolff,Timm Steiner,Ali Modabber,Marc Weber,Frank Hölzle,Horst Fischer +6 more
TL;DR: An algorithm was developed that proposes shapes for reconstruction planning based on given residual mandible geometry parts that can be used as templates for computer-aided manufacturing, e.g., with 3D printing devices that use biocompatible materials.
Journal ArticleDOI
The mineralized collagen for the reconstruction of intra-articular calcaneal fractures with trabecular defects
TL;DR: A retrospective matched-pair analysis justifies and favor the use of MC as a good autograft alternative in displaced intra-articular calcaneal fractures with trabecular defects.
Journal ArticleDOI
Advances in Bone tissue engineering: A fundamental review.
Bruna Maria Manzini,Leonardo Mendes Ribeiro Machado,Pedro Yoshito Noritomi,Jorge Vicente Lopes da Silva +3 more
TL;DR: In this article, the authors provide an overview of the bone tissue, including the role of stem cells and some of the bioactive molecules associated with these processes and suggest future directions for bone tissue engineering area that might be helpful in order to produce biomimetic bone substitutes that become a real alternative to translational medicine.
References
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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Synthetic biodegradable polymers as orthopedic devices.
John Middleton,Arthur J. Tipton +1 more
TL;DR: In this paper, the authors focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired, and an overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
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Complexity in biomaterials for tissue engineering
TL;DR: The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering, and exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.
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Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements.
TL;DR: The main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds.
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Synthetic polymer scaffolds for tissue engineering
TL;DR: This critical review explores how synthetic polymers can be utilised to meet the needs of tissue engineering applications, and how biomimetic principles can be applied to polymeric materials in order to enhance the biological response to scaffolding materials.