Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
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Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction: In vitro and in vivo results.
Ralf Smeets,Mike Barbeck,Henning Hanken,Horst Fischer,Markus Lindner,Max Heiland,Michael Wöltje,Shahram Ghanaati,Andreas Kolk +8 more
TL;DR: The SC in vivo led to complete bone ingrowth with minimal inflammatory reaction adjacent to and within the CSD as compared with controls, and this material composition is ideal for SCs fitting 3D bone defects.
Journal ArticleDOI
Clinical Aspects of Fracture Healing: An Overview
TL;DR: A systematic approach in evaluating fracture union and an understanding of the modern methods to promote fracture healing will allow clinicians to significantly improve the treatment of patients with these injuries.
Journal ArticleDOI
In vitro and in vivo research advancements on the magnesium phosphate cement biomaterials: A review
M. Aminul Haque,Bing Chen +1 more
TL;DR: In this article, the in vitro and in vivo research progresses on the Magnesium phosphate cement (MPC) bioceramics in the orthopedic and dental zones through congregating the vital outcomes of the studies performed by the global scholars.
Journal ArticleDOI
Effect of the Chemical Composition of Simulated Body Fluids on Aerogel-Based Bioactive Composites
TL;DR: It seems to be necessary to re-evaluate hydroxyapatite deposition as proof of bioactivity of artificial bone substitutes when synthetic body fluids analogous in their composition to human blood plasma are used in studies.
Journal ArticleDOI
The innovative application of a novel bone adhesive for facial fracture osteosynthesis-in vitro and in vivo results.
Ralf Smeets,Ralf Smeets,Kira Endres,Gereon Stockbrink,Henning Hanken,Benita Hermanns-Sachweh,Rudolf Marx,Max Heiland,Marco Blessmann,Klaus-Dietrich Wolff,Andreas Kolk +10 more
TL;DR: The observed bonding strengths support implementing this technique in nonload bearing regions, such as the central midface or frontal sinus, facilitating immobilization until bone reunion is complete, for cases in which conventional fixation techniques of screws and plates are insufficient or not possible due to the bone or trauma conditions.
References
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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Synthetic biodegradable polymers as orthopedic devices.
John Middleton,Arthur J. Tipton +1 more
TL;DR: In this paper, the authors focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired, and an overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
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Complexity in biomaterials for tissue engineering
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Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements.
TL;DR: The main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds.
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Synthetic polymer scaffolds for tissue engineering
TL;DR: This critical review explores how synthetic polymers can be utilised to meet the needs of tissue engineering applications, and how biomimetic principles can be applied to polymeric materials in order to enhance the biological response to scaffolding materials.