Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
Citations
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Journal ArticleDOI
Preliminary Results of Bone Regeneration in Oromaxillomandibular Surgery Using Synthetic Granular Graft
Noemi Mazzone,E. Mici,A. Calvo,Michele Runci,Salvatore Crimi,Floriana Lauritano,Evaristo Belli +6 more
TL;DR: The authors report their experience using a synthetic bone substitute in combination with Platelet Rich Fibrin (PRF) and showed a very satisfying bone regeneration without important complications.
Journal ArticleDOI
Applications of Bone Morphogenetic Protein-2: Alternative Therapies in Craniofacial Reconstruction.
TL;DR: BMP-2 is a viable option for craniofacial reconstruction to decrease donor-site morbidity or when alternatives are contraindicated and should currently be reserved as an alternative therapy for complex cases with limited options.
Dissertation
Local targeting of anabolic drug conjugates for treatment of bone loss after tooth extraction
TL;DR: The aim of the research was to demonstrate the impact of a bone-targeting conjugate on the wound healing and bone formation process.
Dissertation
Incorporating self-assembly into robocasting for applications in hard tissue engineering
TL;DR: In this article, a low-temperature deposition modeling (LDM) is used to construct bone scaffolds with tailorable bimodal porosity, which can be used to produce hard tissue substitutes with superior mechanical performance.
Journal ArticleDOI
Preparation and cytological study of collagen/nano-hydroxyapatite/graphene oxide composites.
TL;DR: Antibacterial and MTT experiment confirmed that the mineralized COL/nHA/GO composite material had excellent antibacterial property and biocompatibility, and these results strongly suggested the mineralization of graphene oxide powder is a good candidate biomaterial to be applied in bone tissue engineering.
References
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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Synthetic biodegradable polymers as orthopedic devices.
John Middleton,Arthur J. Tipton +1 more
TL;DR: In this paper, the authors focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired, and an overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
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Complexity in biomaterials for tissue engineering
TL;DR: The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering, and exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.
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Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements.
TL;DR: The main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds.
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Synthetic polymer scaffolds for tissue engineering
TL;DR: This critical review explores how synthetic polymers can be utilised to meet the needs of tissue engineering applications, and how biomimetic principles can be applied to polymeric materials in order to enhance the biological response to scaffolding materials.