Journal ArticleDOI
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
Andreas Kolk,Jörg Handschel,Wolf Drescher,Daniel Rothamel,Frank Kloss,Marco Blessmann,Max Heiland,Klaus-Dietrich Wolff,Ralf Smeets +8 more
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TLDR
An overview of the principles of bone replacement, the types of graft materials available, and future perspectives are presented and a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging is proposed.Abstract:
An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.read more
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Journal ArticleDOI
A rabbit model for experimental alveolar cleft grafting
Mohammad Amjad Kamal,Mohammad Amjad Kamal,Lars Andersson,Rene Tolba,Alexander K. Bartella,Felix Gremse,Frank Hölzle,Peter Kessler,Bernd Lethaus +8 more
TL;DR: The surgical technique was successful in creating a sizable and predictable model forBone grafting material testing and can be used to evaluate various bone grafting materials in regard to efficacy of osteogenesis and healing potential without compromising the health of the animal.
Journal ArticleDOI
Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets.
Elisa Fernández-García,Jordi Guillem-Marti,C. F. Gutiérrez-González,Adolfo Fernández,Maria-Pau Ginebra,Sonia López-Esteban +5 more
TL;DR: In this article, the authors studied the biocompatibility of new micro-nanostructured 3 Y-TZP/Ti materials with 25, 50 and 75 vol.% Ti, which have been successfully obtained by spark slasma sintering technology, as well as to correlate their surface properties (roughness, wettability and chemical composition) with the osteoblastic cell response.
Journal ArticleDOI
Novel silk protein barrier membranes for guided bone regeneration.
Ralf Smeets,Christine Knabe,Andreas Kolk,Michael Rheinnecker,Alexander Gröbe,Max Heiland,Rolf Zehbe,Manuela Sachse,Christian Große-Siestrup,Michael Wöltje,Henning Hanken +10 more
TL;DR: Histomorphometric and histologic evaluation revealed that collagen and β-TCP modified silk membranes supported bone formation and defect repair in guided bone regeneration and defect bridging, and may therefore be advantageous for further supporting bone formation beyond 10 weeks and preventing soft tissue ingrowth from the periphery.
Journal ArticleDOI
Risk Factor Analysis of Graft Failure With Concomitant Cyst Enucleation of the Jaw Bone: A Retrospective Multicenter Study.
TL;DR: This study provides a list of important factors that should be considered by clinicians planning enucleation and simultaneous bone grafting for cysts in the oral and maxillofacial region.
Journal ArticleDOI
Microarchitecture of the Augmented Bone Following Sinus Elevation with an Albumin Impregnated Demineralized Freeze-Dried Bone Allograft (BoneAlbumin) versus Anorganic Bovine Bone Mineral: A Randomized Prospective Clinical, Histomorphometric, and Micro-Computed Tomography Study
Kivovics Márton,Szabó Bence Tamás,Németh Orsolya,Czinkóczky Béla,Dőri Ferenc,Nagy Péter,Dobó-Nagy Csaba,Csönge Lajos,Lacza Zsombor,Mijiritsky Eitan,Szabó György +10 more
TL;DR: While ABBM successfully integrates into the newly formed bone tissue as persisting particles, BoneAlbumin is underway towards complete remodeling with new bone closely resembling that of the intact maxilla.
References
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