Journal ArticleDOI
Delivering affordable cancer care in high-income countries
Richard Sullivan,Jeffrey Peppercorn,Karol Sikora,John Zalcberg,Neal J. Meropol,Eitan Amir,David Khayat,Peter Boyle,Philippe Autier,Ian F. Tannock,Tito Fojo,Jim Siderov,Steve Williamson,Silvia Camporesi,J. Gordon McVie,Arnie Purushotham,Peter Naredi,Alexander M.M. Eggermont,Murray F. Brennan,Michael L. Steinberg,Mark De Ridder,Susan A. McCloskey,Dirk Verellen,Terence Roberts,Guy Storme,Rodney J. Hicks,Peter J. Ell,Bradford R. Hirsch,David P. Carbone,Kevin A. Schulman,Paul Catchpole,David Taylor,Jan Geissler,Nancy G Brinker,David O. Meltzer,David J. Kerr,Matti Aapro +36 more
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Urgent solutions range from re-engineering of the macroeconomic basis of cancer costs (eg, value-based approaches to bend the cost curve and allow cost-saving technologies), greater education of policy makers, and an informed and transparent regulatory system.Abstract:
The burden of cancer is growing, and the disease is becoming a major economic expenditure for all developed countries. In 2008, the worldwide cost of cancer due to premature death and disability (not including direct medical costs) was estimated to be US$895 billion. This is not simply due to an increase in absolute numbers, but also the rate of increase of expenditure on cancer. What are the drivers and solutions to the so-called cancer-cost curve in developed countries? How are we going to afford to deliver high quality and equitable care? Here, expert opinion from health-care professionals, policy makers, and cancer survivors has been gathered to address the barriers and solutions to delivering affordable cancer care. Although many of the drivers and themes are specific to a particular field-eg, the huge development costs for cancer medicines-there is strong concordance running through each contribution. Several drivers of cost, such as over-use, rapid expansion, and shortening life cycles of cancer technologies (such as medicines and imaging modalities), and the lack of suitable clinical research and integrated health economic studies, have converged with more defensive medical practice, a less informed regulatory system, a lack of evidence-based sociopolitical debate, and a declining degree of fairness for all patients with cancer. Urgent solutions range from re-engineering of the macroeconomic basis of cancer costs (eg, value-based approaches to bend the cost curve and allow cost-saving technologies), greater education of policy makers, and an informed and transparent regulatory system. A radical shift in cancer policy is also required. Political toleration of unfairness in access to affordable cancer treatment is unacceptable. The cancer profession and industry should take responsibility and not accept a substandard evidence base and an ethos of very small benefit at whatever cost; rather, we need delivery of fair prices and real value from new technologies.read more
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Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries.
Claudia Allemani,Tomohiro Matsuda,Veronica Di Carlo,Rhea Harewood,Melissa Matz,Maja Niksic,Audrey Bonaventure,Mikhail Valkov,Christopher J. Johnson,Jacques Estève,Olufemi Ogunbiyi,Gulnar Azevedo e Silva,Wanqing Chen,Sultan Eser,Gerda Engholm,Charles A. Stiller,Alain Monnereau,Ryan Woods,Otto Visser,Gek Hsiang Lim,Joanne F. Aitken,Hannah K. Weir,Michel P Coleman,S Bouzbid,M. Hamdi-Cherif,Zoubida Zaidi,K Meguenni,D Regagba,S Bayo,T Cheick Bougadari,Shyam Manraj,K Bendahhou,A. Fabowale,Dee Bradshaw,Nontuthuzelo Somdyala,I Kumcher,Florencia Moreno,G.H. Calabrano,S.B. Espinola,B Carballo Quintero,R Fita,M.C. Diumenjo,W.D. Laspada,S.G. Ibañez,Carlos Anselmo Lima,P.C.F. De Souza,K Del Pino,C Laporte,Maria Paula Curado,JC de Oliveira,C.L.A. Veneziano,D.B. Veneziano,M.R.D.O. Latorre,L.F. Tanaka,M S Rebelo,M O Santos,J.C. Galaz,M Aparicio Aravena,J Sanhueza Monsalve,D.A. Herrmann,S Vargas,Victor M. Herrera,Claudia Uribe,Luis Eduardo Bravo,L S Garcia,N.E. Arias-Ortiz,D Morantes,Daniel Jurado,M C Yépez Chamorro,S Delgado,M Ramirez,Y H Galán Alvarez,P Torres,F Martínez-Reyes,L Jaramillo,R Quinto,J Castillo,M Mendoza,Patricia Cueva,J.G. Yépez,B Bhakkan,J Deloumeaux,C Joachim,J Macni,R Carrillo,J Shalkow Klincovstein,R Rivera Gomez,E Poquioma,Guillermo Tortolero-Luna,D Zavala,Rafael Alonso,Enrique Barrios,A Eckstrand,C Nikiforuk,G Noonan,D Turner,E Kumar,B Zhang,F.R. McCrate,S Ryan,Michael F. MacIntyre,Nathalie Saint-Jacques,Diane Nishri,Carol McClure,K.A. Vriends,S Kozie,H Stuart-Panko,T Freeman,J.T. George,J.T. Brockhouse,D.K. O'Brien,A Holt,L Almon,S Kwong,Cyllene R. Morris,Randi K. Rycroft,Lloyd Mueller,C E Phillips,Heath Brown,B Cromartie,Ann G. Schwartz,F Vigneau,G M Levin,B Wohler,R Bayakly,Kevin C. Ward,Scarlett Lin Gomez,M McKinley,Rosemary D. Cress,M.D. Green,K Miyagi,L P Ruppert,Charles F. Lynch,B Huang,Thomas C. Tucker,Dennis Deapen,L Liu,M.C. Hsieh,X.C. Wu,M Schwenn,S.T. Gershman,R.C. Knowlton,G Alverson,Glenn Copeland,S Bushhouse,DB Rogers,J Jackson-Thompson,D Lemons,H J Zimmerman,M Hood,J Roberts-Johnson,Judith R. Rees,B Riddle,Karen Pawlish,Antoinette M. Stroup,C Key,Charles L. Wiggins,Amy R. Kahn,Maria J. Schymura,S Radhakrishnan,C Rao,L K Giljahn,R M Slocumb,R E Espinoza,F Khan,K G Aird,T Beran,J.J. Rubertone,S.J. Slack,Luz Stella García,D.L. Rousseau,Tiffany Janes,Stephen M. Schwartz,Susan Bolick,D.M. Hurley,M.A. Whiteside,P Miller-Gianturco,Melanie Williams,K Herget,Christopher Sweeney,A T Johnson,M.B. Keitheri Cheteri,P Migliore Santiago,S E Blankenship,S Farley,R Borchers,R Malicki,JR Espinoza,J Grandpre,Reda J. Wilson,Brenda K. Edwards,A Mariotto,Y Lei,N Wang,J.S. Chen,Y Zhou,Y T He,G.H. Song,X.P. Gu,D Mei,H J Mu,H.M. Ge,T H Wu,Y Y Li,D.L. Zhao,F Jin,J.H. Zhang,F.D. Zhu,Q Junhua,Y L Yang,C X Jiang,W Biao,J Wang,Q.L. Li,H Yi,X Zhou,J Dong,W Li,F X Fu,S Z Liu,J.G. Chen,J Zhu,Y H Li,Y Q Lu,M Fan,S.Q. Huang,G.P. Guo,H Zhaolai,K Wei,H Zeng,Anna Demetriou,W.K. Mang,K.C. Ngan,A.C. Kataki,M Krishnatreya,P.A. Jayalekshmi,P Sebastian,A Nandakumar,R Malekzadeh,G Roshandel,Lital Keinan-Boker,Barbara G. Silverman,H Ito,H Nakagawa,M Sato,F Tobori,I Nakata,N Teramoto,M Hattori,Y Kaizaki,F Moki,H Sugiyama,M Utada,M Nishimura,K Yoshida,K Kurosawa,Y Nemoto,H Narimatsu,M Sakaguchi,S Kanemura,M Naito,R Narisawa,Isao Miyashiro,Kayo Nakata,S Sato,M Yoshii,I Oki,N Fukushima,A Shibata,K Iwasa,C Ono,Omar Nimri,K.W. Jung,Y.J. Won,Eiman Alawadhi,Amani A. El-Basmi,A Ab Manan,F Adam,E Sanjaajmats,U Tudev,C Ochir,A.H.M. Al Khater,M.M. El Mistiri,Y Y Teo,Chun-Ju Chiang,Wen-Chung Lee,Rangsiya Buasom,S Sangrajrang,Supot Kamsa-ard,Surapon Wiangnon,Karnchana Daoprasert,Donsuk Pongnikorn,Atit Leklob,S Sangkitipaiboon,S.L. Geater,Hutcha Sriplung,O Ceylan,I Kög,O Dirican,T Köse,T Gurbuz,F E Karaşahin,D Turhan,U Aktaş,Y Halat,Cankut Yakut,M Altinisik,Y Cavusoglu,A Türkköylü,N Üçüncü,Monika Hackl,Anna Zborovskaya,O.V. Aleinikova,K. Henau,L. Van Eycken,Zdravka Valerianova,M R Yordanova,M. Sekerija,Ladislav Dušek,M. Zvolský,Hans H. Storm,Kaire Innos,Margit Mägi,Nea Malila,K. Seppä,J Jégu,Michel Velten,E Cornet,Xavier Troussard,Anne Marie Bouvier,A.V. Guizard,Véronique Bouvier,G. Launoy,Patrick Arveux,Marc Maynadié,Morgane Mounier,Anne-Sophie Woronoff,M Daoulas,M. Robaszkiewicz,Jacqueline Clavel,S Goujon,Brigitte Lacour,Isabelle Baldi,C Pouchieu,B Amadeo,G Coureau,S Orazio,P M Preux,F Rharbaoui,E Marrer,Brigitte Trétarre,M. Colonna,P Delafosse,K Ligier,S Plouvier,A Cowppli-Bony,Florence Molinié,Simona Bara,O Ganry,Bénédicte Lapôtre-Ledoux,Pascale Grosclaude,Nadine Bossard,Z Uhry,Freddie Bray,Marion Piñeros,Roland Stabenow,H Wilsdorf-Köhler,Andrea Eberle,Sabine Luttmann,I Löhden,Alice Nennecke,Joachim Kieschke,Eunice Sirri,Katharina Emrich,Sylke Ruth Zeissig,Bernd Holleczek,Nora Eisemann,Alexander Katalinic,R.A. Asquez,V Kumar,Eleni Petridou,Elinborg J Olafsdottir,Laufey Tryggvadottir,Kerri Clough-Gorr,Paul M. Walsh,H Sundseth,Guido Mazzoleni,F Vittadello,E Coviello,Francesco Cuccaro,Rocco Galasso,Giuseppe Sampietro,Adriano Giacomin,Michele Magoni,Antonino Ardizzone,Angelo D'Argenzio,Marine Castaing,G Grosso,A M Lavecchia,A Sutera Sardo,G Gola,Luciana Gatti,Paolo Ricci,Stefano Ferretti,Diego Serraino,A Zucchetto,M Celesia,Rosa Filiberti,Fabio Pannozzo,Anna Melcarne,F Quarta,Antonio Russo,Giuliano Carrozzi,Claudia Cirilli,L Cavalieri D’oro,M Rognoni,M Fusco,Maria Francesca Vitale,M Usala,Rosanna Cusimano,Walter Mazzucco,Maria Michiara,P Sgargi,Lorenza Boschetti,E Borciani,P Seghini,Milena Maule,Franco Merletti,R. Tumino,Pamela Mancuso,Massimo Vicentini,Tiziana Cassetti,Romano Sassatelli,Fabio Falcini,S Giorgetti,Anna Luisa Caiazzo,R Cavallo,Rosaria Cesaraccio,D R Pirino,M.L. Contrino,F Tisano,A.C. Fanetti,S Maspero,Simona Carone,A Mincuzzi,Giuseppa Candela,Tiziana Scuderi,M.A. Gentilini,Silvano Piffer,Stefano Rosso,Alessandro Barchielli,Adele Caldarella,Fortunato Bianconi,Fabrizio Stracci,Paolo Contiero,Giovanna Tagliabue,Massimo Rugge,Manuel Zorzi,S Beggiato,Angelita Brustolin,Franco Berrino,Gemma Gatta,Milena Sant,Carlotta Buzzoni,Lucia Mangone,R. Capocaccia,R. De Angelis,Roberto Zanetti,A Maurina,Santa Pildava,N Lipunova,I Vincerževskiené,Dominic Agius,Neville Calleja,Sabine Siesling,Siri Larønningen,Bjørn Møller,A Dyzmann-Sroka,Maciej Trojanowski,Stanisław Góźdź,R. Mężyk,T Mierzwa,L Molong,Jadwiga Rachtan,S Szewczyk,J. Błaszczyk,Kamila Kepska,B Kościańska,K Tarocińska,M Zwierko,K Drosik,K M Maksimowicz,E Purwin-Porowska,E Reca,J Wójcik-Tomaszewska,A Tukiendorf,M. Grądalska-Lampart,A.U. Radziszewska,A Gos,M Talerczyk,M Wyborska,J.A. Didkowska,U Wojciechowska,Magdalena Bielska-Lasota,G. Forjaz de Lacerda,R.A. Rego,Joana Bastos,MA Silva,Luís Antunes,J Laranja Pontes,A. Mayer-da-Silva,Ana Miranda,L M Blaga,Daniela Coza,L Gusenkova,O Lazarevich,O Prudnikova,D M Vjushkov,A G Egorova,A E Orlov,L A Kudyakov,L V Pikalova,J Adamcik,C. Safaei Diba,Maja Primic-Žakelj,Vesna Zadnik,Nerea Larrañaga,A. López De Munain,A A Herrera,R Redondas,Rafael Marcos-Gragera,M.L. Vilardell Gil,E Molina,M J Sánchez Perez,P Franch Sureda,M Ramos Montserrat,M-D Chirlaque,Carmen Navarro,Eva Ardanaz,M M Guevara,R Fernández-Delgado,Rafael Peris-Bonet,Marià Carulla,Jaume Galceran,C Alberich,M Vicente-Raneda,Sofia Khan,David Pettersson,Paul W. Dickman,I Avelina,K Staehelin,B Camey,C. Bouchardy,R Schaffar,H. Frick,C. Herrmann,Jean-Luc Bulliard,M Maspoli-Conconi,Claudia E. Kuehni,S M Redmond,Andrea Bordoni,L Ortelli,Arnaud Chiolero,Isabelle Konzelmann,K.L. Matthes,Sabine Rohrmann,J Broggio,Jem Rashbass,Deirdre Fitzpatrick,Anna Gavin,D I Clark,Andrew Deas,Dyfed Wyn Huws,Ceri White,L Montel,Bernard Rachet,Adrian Turculet,Richard Stephens,E Chalker,H Phung,Richard Walton,H You,Steven Guthridge,F Johnson,P Gordon,K D'Onise,K Priest,B.C. Stokes,A Venn,Helen Farrugia,Vicky Thursfield,J Dowling,David C. Currow,J Hendrix,C Lewis +594 more
TL;DR: For most cancers, 5-year net survival remains among the highest in the world in the USA and Canada, in Australia and New Zealand, and in Finland, Iceland, Norway, and Sweden, while for many cancers, Denmark is closing the survival gap with the other Nordic countries.
Journal ArticleDOI
Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)
Claudia Allemani,Hannah K. Weir,Helena Carreira,Rhea Harewood,Devon Spika,Xiao-Si Wang,Finian Bannon,Jane V Ahn,Christopher J. Johnson,Audrey Bonaventure,Rafael Marcos-Gragera,Charles A. Stiller,Gulnar Azevedo e Silva,Wanqing Chen,Olufemi Ogunbiyi,Bernard Rachet,Matthew J Soeberg,Hui You,Tomohiro Matsuda,Magdalena Bielska-Lasota,Hans H. Storm,Thomas C. Tucker,Michel P Coleman +22 more
TL;DR: The aim was to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control.
Journal ArticleDOI
The burden of disease in older people and implications for health policy and practice
Martin Prince,Fan Wu,Yanfei Guo,Luis Miguel Francisco Gutierrez Robledo,Martin O'Donnell,Richard Sullivan,Salim Yusuf +6 more
TL;DR: The authors in this article found that 30.23% of the total global burden of disease is attributable to disorders in people aged 60 years and older, and the leading contributors to disease burden in older people are cardiovascular diseases, malignant neoplasms (15·1%), chronic respiratory diseases (9·5%), musculoskeletal diseases (7·5), and neurological and mental disorders (6·6%).
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Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis
TL;DR: A committee of experts to examine the quality of cancer care in the United States and formulate recommendations for improvement presents the committee’s findings and recommendations.
Journal ArticleDOI
Economic burden of cancer across the European Union: a population-based cost analysis
TL;DR: The economic burden of cancer in the EU is estimated to be €126 billion in 2009, with health care accounting for €51·0 billion (40%).
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TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
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TL;DR: Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
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