Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Hydrogel/nanoadjuvant-mediated combined cell vaccines for cancer immunotherapy
TL;DR: In this paper, the authors proposed a biomaterial-mediated combined cell vaccines for immunotherapy, which combines tumor cell and dendritic cells with a cyclodextrin-polyethylene glycol hydrogel and a cytosine-phosphate-guanine (CpG) nanoadjuvant.
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Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies.
Aleksandr V. Sokolov,Samira A Dostdar,Misty M. Attwood,Aleksandra A. Krasilnikova,Anastasia A. Ilina,Amina Sh. Nabieva,Anna A. Lisitsyna,Vladimir N. Chubarev,Vadim V. Tarasov,Helgi B. Schiöth +9 more
TL;DR: In this paper, a comprehensive quantitative analysis and discussion of the brain cancer drug discovery field, including classification of drug, targets, and therapies, is provided, along with an extensive overview of the drug discovery fields in brain cancer, shifts that have been happening in recent years, and challenges that are likely to come.
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Accumulation of dysfunctional tumor-infiltrating PD-1+ DCs links PD-1/PD-L1 blockade immunotherapeutic response in cervical cancer
Yumeng Wang,Junjun Qiu,Xin-yu Qu,Jing Peng,Chong Lu,Meng Zhang,Mingxing Zhang,Xingling Qi,Bin Lv,Jingjing Guo,Chenyang Guo,Guiling Li,Keqin Hua +12 more
TL;DR: In this paper , the authors identified a population of PD-1+ DCs in the tumor microenvironment (TME) of cervical cancer (CC) and correlated their accumulation with advanced stages, elevated preoperative squamous cell carcinoma antigen levels and lymph-vascular space invasion.
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Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis.
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The immunology of SARS-CoV-2 infection, the potential antibody based treatments and vaccination strategies.
Zahra Payandeh,Zahra Payandeh,Niloufar Mohammadkhani,Niloufar Mohammadkhani,Mohsen Nabi Afjadi,Saeed Khalili,Masoumeh Rajabibazl,Zahra Houjaghani,Masoomeh Dadkhah +8 more
TL;DR: In this paper, potential antibody-based treatments especially monoclonal antibodies (mAbs) that may exert a potential role in treatment as well as developing vaccination strategies against COVID-19.
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