Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Применение биомедицинских клеточных продуктов для лечения онкологических заболеваний
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Immune response and treatment targets of chronic hepatitis B virus infection: innate and adaptive immunity
Peiyu Zheng,Y Dou,Qinying Wang +2 more
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Comparitive study of dendritic cell vaccine preparation with presence and absence of malpighia emarginata fruit extract using tumor rna transfection method: a promising approach for prostate cancer
TL;DR: In this article , mature and immature dendritic cells were obtained in-vitro by adding specific cytokines to monocyte cell culture containing Malpighia emarginata fruit extract in the presence of prostate specific antigen (PSA), and their results were compared to those obtained without using the fruit extract.
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Single-component lipid nanoparticles for engineering SOCS1 gene-silenced dendritic cells to boost tumor immunotherapy.
Zexuan Yu,Meng-Chao Wu,Yingshuang Huang,Yishu Wang,Yijun Chen,Qiulin Long,Ziming Lin,Lingjing Xue,Caoyun Ju,Can Zhang +9 more
TL;DR: In this paper , single component lipid nanoparticles comprising a solely cationic lipid (OA2) for introducing siRNA into mouse Dendritic cells in order to inhibit the immunosuppressive gene and boost the effector responses of DC-based therapy.
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