Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
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Hyperthermia Targeting the Tumor Microenvironment Facilitates Immune Checkpoint Inhibitors.
TL;DR: A cluster of immune-related factors that not only make hyperthermia a treatment capable of defending against cancer but also make hyperThermia a reliable treatment that creates a type I-like tumor microenvironment in complementary for the enhancement of the ICI.
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FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
Vijayashree Mysore,Xavier Cullere,Joseph R. Mears,Florencia Rosetti,Koshu Okubo,Pei X. Liew,Fan Zhang,Iris K. Madera-Salcedo,Frank Rosenbauer,Richard Stone,Jon C. Aster,Ulrich H. von Andrian,Andrew H. Lichtman,Soumya Raychaudhuri,Tanya N. Mayadas +14 more
TL;DR: In this article, an anti-FcγRIIIB-antigen conjugate-induced conversion of neutrophils to immunogenic dendritic cells may represent a possible immunotherapy for cancer and infectious diseases.
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Engineered nanomaterials for synergistic photo-immunotherapy.
TL;DR: Wang et al. as discussed by the authors investigated the latest strategies on engineering nanomaterials to enhance the anti-cancer efficiency of synergistic photo-immunotherapy, with emphasis on the activation of anti-tumor immune response, the reversal of tumor immunosuppressive microenvironment (TIME), the regulation of the interaction between immunosensressive cells and tumor cells, the infiltration of immune cells and improved efficiency of photo-IMmunotherapy-induced ICD.
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Nucleic acid nanotechnology for cancer treatment.
Jun-O Jin,Jun-O Jin,Gyurin Kim,Juyoung Hwang,Kyung Ho Han,Minseok Kwak,Minseok Kwak,Peter C.W. Lee +7 more
TL;DR: Studies on the applications of NA in cancer treatment, recent research trends, and the limitations and prospects of specific NA-mediated gene therapy and immunotherapy for cancer treatment are discussed.
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Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer.
Taylor T. Chrisikos,Yifan Zhou,Natalie Slone,Rachel L. Babcock,Stephanie S. Watowich,Stephanie S. Watowich,Haiyan S. Li +6 more
TL;DR: The importance of DCs in anti-tumor immunity and immune therapy is highlighted, with the overall goal of improving knowledge of tumor-associated factors and intrinsic DC signaling cascades that influence DC function in cancer.
References
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