Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Journal ArticleDOI
Photothermal-Activatable Fe3O4 Superparticle Nanodrug Carriers with PD-L1 Immune Checkpoint Blockade for Anti-metastatic Cancer Immunotherapy
Rui Ge,Cangwei Liu,Xue Zhang,Wenjing Wang,Binxi Li,Jie Liu,Yi Liu,Hongchen Sun,Daqi Zhang,Yuchuan Hou,Hao Zhang,Bai Yang +11 more
TL;DR: Findings suggest that Fe3O4-R837 SP-involved PTT can significantly potentiate the systemic therapeutic efficiency of PD-L1 checkpoint blockade therapy by activating both innate and adaptive immune systems in the body.
Journal ArticleDOI
Antitumor effects of immunity-enhancing traditional Chinese medicine.
TL;DR: This review will summarize research progress of antitumor TCM that regulates the immune system, including both innate immunity, such as macrophages, dendritic cells, natural killer cells and MDSCs, and adaptive immunity, including CD4+/CD8+ T lymphocytes, regulatory T cells (Tregs) and B cells.
Journal ArticleDOI
Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity
Sreekumar Balan,Sreekumar Balan,Catharina Arnold-Schrauf,Abdenour Abbas,Norbert Couespel,Juliette Savoret,Francesco Imperatore,Alexandra-Chloé Villani,Thien-Phong Vu Manh,Nina Bhardwaj,Marc Dalod +10 more
TL;DR: A DC differentiation method from human CD34+ precursors leading to high yields of plasmacytoid DCs and both types of conventional DCs, and a pre-terminal differentiation state for each DC type is discovered, characterized by high expression of cell-cycle genes and lack of XCR1 in the case of cDC1.
Journal ArticleDOI
Dendritic Cell Cancer Therapy: Vaccinating the Right Patient at the Right Time.
Wouter W. van Willigen,Martine Bloemendal,Winald R. Gerritsen,Gerty Schreibelt,I. Jolanda M. de Vries,Kalijn F. Bol +5 more
TL;DR: With the success of immune checkpoint inhibition in several malignancies and considering the plethora of other treatment modalities being developed, it is of utmost importance to delineate the position of dendritic cell therapy in the treatment landscape of cancer.
Journal ArticleDOI
Trial watch: Dendritic cell-based anticancer immunotherapy.
Abhishek D. Garg,Monica Vara Perez,Marco B.E. Schaaf,Patrizia Agostinis,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi +7 more
TL;DR: This Trial Watch surveys the latest trends in the preclinical and clinical development of DC-based anticancer therapeutics and highlights how the emergence of immune checkpoint blockers and adoptive T-cell transfer-based approaches has modified the clinical niche within the wide cancer immunotherapy landscape.
References
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