Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Journal ArticleDOI
Inducing Ectopic T Cell Clusters Using Stromal Vascular Fraction Spheroid‐Based Immunotherapy to Enhance Anti‐Tumor Immunity
Jaewon Lee,Bum Chul Park,Na Yoon Jang,Sihyeon Lee,Youngkyu Cho,Prashant Sharma,Sang Won Byun,Hyeongseok Jeong,Yun-Hui Jeon,Uni Park,Hyo Jin Ro,Hyo Ree Park,Yuri Kim,Dong Sup Lee,Seok Chung,Young Keun Kim,Nam Hyuk Cho +16 more
TL;DR: Stromal vascular fraction from adipose tissues can enhance dendritic cell (DC)‐mediated T cell immunity by inducing ectopic T lymphocyte clusters and elicits enhanced antigen‐specific immune response and anti‐tumoral immunity in mice, illustrating the potential for a novel immunotherapeutic design using SVF as a structural scaffold for TLS.
Journal ArticleDOI
Engineering magnetic nano-manipulators for boosting cancer immunotherapy
Bin Yan,Siyao Wang,Chen Liu,Nana Wen,Hugang Li,Yihan Zhang,Hao Wang,Ziyi Xi,Yi Lv,Haiming Fan,Xiaoli Liu +10 more
TL;DR: In this article , magnetic nanoparticles (MNPs) as a powerful manipulator are used for comprehensively regulating the immune system in vivo due to their unique magnetically responsive properties and high biocompatibility.
Journal ArticleDOI
A therapeutic DC vaccine with maintained immunological activity exhibits robust anti-tumor efficacy.
Yichao Lu,Yingying Shi,Yu Liu,Zhenyu Luo,Junlei Zhang,Mengshi Jiang,Xiang Li,Xu Li Liu,Xuemeng Guo,Bing Qin,Hang Yin,Yongzhong Du,Yu Qiu,Yan Lou,Guannan Guan,Lihua Luo,Jian You +16 more
TL;DR: In this article , a KIRA6-loaded α-Tocopherol nanoemulsion (KT-NE) was used to ameliorate oxidative stress and endoplasmic reticulum (ER) stress in the dysfunctional lipid-laden TC-DC.
Journal ArticleDOI
Comparison of the PU.1 transcriptional regulome and interactome in human and mouse inflammatory dendritic cells
Maaike R. Scheenstra,Maaike R. Scheenstra,Patricia Martínez-Botía,Andrea Acebes-Huerta,Rutger W W Brouwer,Noemí Caballero-Sánchez,Nynke Gillemans,Pieter De Bleser,Benjamin Nota,Iris M. De Cuyper,Vishal Salunkhe,Andrea M. Woltman,Lianne van de Laar,Erikjan Rijkers,Jeroen Demmers,Wilfred F. J. van IJcken,Sjaak Philipsen,Timo K. van den Berg,Taco W. Kuijpers,Laura Gutierrez,Laura Gutierrez,Laura Gutierrez +21 more
TL;DR: The results portray PU.1 as a pivotal factor that plays an important role in the regulation of genes required for proper DC activation and function, and assures the repression of nonlineage genes.
Book ChapterDOI
Artificial Life and Therapeutic Vaccines Against Cancers that Originate in Viruses
TL;DR: The methods that through a process of artificial life, allow to simulate the interactions that arise between human immune system, pathogen (viruses as etiological agents of cancer), and therapeutic vaccines to treat lesions that originates in the activity of this type of pathogen are described.
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