Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Journal ArticleDOI
Tumor-derived extracellular vesicles: molecular parcels that enable regulation of the immune response in cancer
TL;DR: The current knowledge of the functional cargo contained within EVs is described, with a focus on tumor microvesicles, and the emerging theory of how EVs support immune suppression in cancer is reviewed.
Journal ArticleDOI
Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy.
TL;DR: It is investigated whether in vitro generated Mo-DCs from MM patients (MM- DCs) possess impaired functionality, thus contributing to the limited success of DC vaccines, and a need to look for alternative sources of DCs.
Journal ArticleDOI
In Situ Manipulation of Dendritic Cells by an Autophagy-Regulative Nanoactivator Enables Effective Cancer Immunotherapy.
Yi Wang,Yi Wang,Yao-Xin Lin,Yao-Xin Lin,Jie Wang,Jie Wang,Sheng-Lin Qiao,Sheng-Lin Qiao,Yuying Liu,Wenqian Dong,Junqing Wang,Hong-Wei An,Hong-Wei An,Chao Yang,Muhetaerjiang Mamuti,Muhetaerjiang Mamuti,Lei Wang,Bo Huang,Hao Wang,Hao Wang +19 more
TL;DR: In situ DCs manipulation by autophagy induction is a promising strategy for antigen presentation enhancement and tumor elimination and in vivo experiments show that the nanoactivators successfully reduce tumor and prolong murine survival.
Journal ArticleDOI
Predictors of Response to Autologous Dendritic Cell Therapy in Glioblastoma Multiforme
Chia-Ing Jan,Wan Chen Tsai,Horng-Jyh Harn,Woei Cherng Shyu,Ming Chao Liu,Hsin Man Lu,Shao Chih Chiu,Der Yang Cho +7 more
TL;DR: For patients receiving DC vaccine adjuvant therapy, better outcomes are predicted in patients with younger age, with TILs or PBMCs with lower PD-1+/CD8+ ratio, with gross tumor resection, and receiving CCRT.
Journal ArticleDOI
Microfluidic Cell Stretching for Highly Effective Gene Delivery into Hard-to-Transfect Primary Cells
TL;DR: The intracellular delivery platform developed in the present study enables a high delivery efficiency (up to 98%), easy operation (single-step), low material cost (<$1), high scalability, minimal cell perturbation, and cell type/cargo insensitive delivery, providing a practical and robust approach anticipated to critically impact cell-based research.
References
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Journal ArticleDOI
Toll-like receptor signalling
Shizuo Akira,Kiyoshi Takeda +1 more
TL;DR: Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
Journal ArticleDOI
Immunobiology of Dendritic Cells
Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
Journal ArticleDOI
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
Naiyer A. Rizvi,Naiyer A. Rizvi,Matthew D. Hellmann,Matthew D. Hellmann,Alexandra Snyder,Alexandra Snyder,Pia Kvistborg,Vladimir Makarov,Jonathan J. Havel,William Lee,Jianda Yuan,Phillip Wong,Teresa S. Ho,Martin L. Miller,Natasha Rekhtman,Andre L. Moreira,Fawzia Ibrahim,Cameron Bruggeman,Billel Gasmi,Roberta Zappasodi,Yuka Maeda,Chris Sander,Edward B. Garon,Taha Merghoub,Jedd D. Wolchok,Jedd D. Wolchok,Ton N. Schumacher,Timothy A. Chan,Timothy A. Chan +28 more
TL;DR: Treatment efficacy was associated with a higher number of mutations in the tumors, and a tumor-specific T cell response paralleled tumor regression in one patient, suggesting that the genomic landscape of lung cancers shapes response to anti–PD-1 therapy.
Journal ArticleDOI
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
Philip W. Kantoff,Celestia S. Higano,N. Shore,E. Roy Berger,Eric J. Small,David F. Penson,Charles H. Redfern,Anna C. Ferrari,Robert Dreicer,Robert B. Sims,Yi Xu,Mark W. Frohlich,Paul F. Schellhammer +12 more
TL;DR: The use of sipuleucel-T prolonged overall survival among men with metastatic castration-resistant prostate cancer and immune responses to the immunizing antigen were observed in patients who received sipuleUcel- T.
Journal ArticleDOI
Neoantigens in cancer immunotherapy
TL;DR: Observations indicate that neoantigen load may form a biomarker in cancer immunotherapy and provide an incentive for the development of novel therapeutic approaches that selectively enhance T cell reactivity against this class of antigens.
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