Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Bidirectional Crosstalk between Therapeutic Cancer Vaccines and the Tumor Microenvironment: Beyond Tumor Antigens
Siwei Zhang,Han Wang,Xiaohong Ding,Yuling Xiao,Zhi Ming Shao,Chao You,Yalan Gu,Yi-Zhou Jiang +7 more
TL;DR: In this paper , the authors summarized recent progress on the interaction between therapeutic cancer vaccines and the tumor microenvironment (TME), and found that vaccine resistance, innate immunosuppressive TME components and acquired resistance caused by vaccination are both involved.
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Potential Vaccines for Treating Crohn's Disease
Mohammad Rostami-Nejad,Mohammad Reza Hairi Yazdi,Shekoufeh Nikfar,Ali Rezaie,Mohammad Abdollahi +4 more
TL;DR: Most available therapeutic opportunities in the last decade, especially the possibility of vaccines against CD, are reviewed and also the type of resident antigen-presenting cells and their traffic in different parts of GIT, may vary case by case.
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Genetically modified cancer vaccines: Current status and future prospects
TL;DR: This review will discuss the major approaches used to develop genetically modified cancer vaccines and explore recent advances to increase the understanding of engineered cancer vaccines.
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Tumor-Infiltrating Dendritic Cells: Decisive Roles in Cancer Immunosurveillance, Immunoediting, and Tumor T Cell Tolerance
Theodora Katopodi,Savvas Petanidis,Charalampos Charalampidis,Ioanna P. Chatziprodromidou,Panagiotis Eskitzis,Drosos Tsavlis,Paul Zarogoulidis,Chris Kosmidis,Dimitrios Matthaios,Konstantinos Porpodis +9 more
TL;DR: Tumor-infiltrating dendritic cells play a crucial role in modulating the immune response, and innovative approaches for therapeutic modulation of these immunosuppressive DCs are highlighted which is necessary for future personalized therapeutic approaches.
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Predicting diagnostic gene expression profiles associated with immune infiltration in patients with lupus nephritis
TL;DR: In this article , the authors used least absolute shrinkage and selection operator (LASSO) and support vector machine-recursive feature elimination (SVM-RFE) to identify potential diagnostic markers of lupus nephritis (LN) based on bioinformatics and machine learning and to explore the significance of immune cell infiltration in this pathology.
References
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