Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Journal ArticleDOI
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy
TL;DR: By disentangling the general aspects of DC biology, rationales for the design of next generation DC vaccines enabling to exploit and manipulate the described pathways for the purpose of cancer immunotherapy in vivo are provided.
Journal ArticleDOI
Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses.
Aranzazu Cruz-Adalia,Guillermo Ramirez-Santiago,Jesús Osuna-Pérez,Mónica Torres-Torresano,Virgina Zorita,Ana Martínez-Riaño,Viola Boccasavia,Aldo Borroto,Gloria Martínez del Hoyo,José María González-Granado,Balbino Alarcón,Francisco Sánchez-Madrid,Esteban Veiga +12 more
TL;DR: It is shown that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response, highlighting the potential of CD4- T cells as a tool for cancer immunotherapy.
Journal ArticleDOI
Plant-derived polysaccharides activate dendritic cell-based anti-cancer immunity
TL;DR: The relative potencies of individual PDPs to induce both phenotypic and functional maturation in DCs, their relative abilities to activate anti-cancer immunity, the possible mechanisms by which they act and also the challenges surrounding their clinical application are reviewed.
Journal ArticleDOI
Lentiviral Vector-Based Dendritic Cell Vaccine Suppresses HIV Replication in Humanized Mice.
TL;DR: The development of a lentiviral vector-based dendritic cell (DC) vaccine in which HIV-1 antigen is co-expressed with CD40 ligand (CD40L) and a soluble, high-affinity programmed cell death 1 (PD-1) dimer and introduction of the soluble PD-1 dimer into a vector accelerated the antiviral response.
Journal ArticleDOI
An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells
Michele Tomasicchio,Lynn Semple,Aliasgar Esmail,Richard Meldau,Philippa Randall,Anil Pooran,Malika Davids,Lydia Cairncross,David Anderson,Jennifer Downs,Francois Malherbe,Nicolas Novitzky,Eugenio Panieri,Suzette Oelofse,Rolanda Londt,Thurandrie Naiker,Keertan Dheda +16 more
TL;DR: A DC vaccine that is cytotoxic to autologous breast cancer cells in vitro is developed and the tools and technology generated here will be applied to a phase I/IIa clinical trial.
References
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TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
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