Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Journal ArticleDOI
Antigen Delivery to DEC205+ Dendritic Cells Induces Immunological Memory and Protective Therapeutic Effects against HPV-Associated Tumors at Different Anatomical Sites.
Mariângela de Oliveira Silva,Bianca da Silva Almeida,Natiely Silva Sales,Mariana O. Diniz,Luana R.M.M. Aps,Karine Bitencourt Rodrigues,Jamile Ramos da Silva,Ana Carolina Ramos Moreno,Bruna F.M.M. Porchia,Fernando Bandeira Sulczewski,Silvia Beatriz Boscardin,Luís Carlos de Souza Ferreira +11 more
TL;DR: In this article, the authors employed antibody-antigen conjugates targeting a specific DC C-type lectin receptor, and genetically fused the anti-DEC205 monoclonal antibody to the type 16 human papillomavirus (HPV-16) E7 oncoprotein to create a therapeutic vaccine to treat HPVassociated tumors in syngeneic mouse tumor models.
Journal ArticleDOI
Variegated Outcomes of T Cell Activation by Dendritic Cells in the Steady State
TL;DR: In this article , the diversity of fates and functions of T cells involved in the opposing immunogenic and tolerogenic processes induced in the steady state by the relevant mechanisms of systemic cDC present in murine peripheral lymphoid organs.
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Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells.
Saskia Schmitt,Siret Tahk,Alina Lohner,Gerulf Hänel,Andreas Maiser,Martina Hauke,Lubna Patel,Maurine Rothe,Christine Josenhans,Heinrich Leonhardt,Marieke Griffioen,Katrin Deiser,Nadja C. Fenn,Karl-Peter Hopfner,Marion Subklewe,Marion Subklewe +15 more
TL;DR: A multifunctional antibody construct integrating the DC-specific delivery of viral- or tumor-associated antigens and DC activation by TLR ligation in one molecule was generated and it was demonstrated that TLR5 ligation improved the efficacy of the molecule.
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The DDR-related gene signature with cell cycle checkpoint function predicts prognosis, immune activity, and chemoradiotherapy response in lung adenocarcinoma
TL;DR: In this paper , the authors used the least absolute shrinkage and selection operator (LASSO) regression to construct a prognosis model for lung adenocarcinoma (LUAD) patients.
Journal ArticleDOI
Adoptive cell therapy for acute myeloid leukemia
TL;DR: The clinical application and advancement of donor lymphocyte infusion, chimeric-antigen receptor (CAR) T cell therapy, natural killer (NK) cell therapy and dendritic cell vaccination for AML are reviewed, hopefully providing an overview of clinical aspects of advances in adoptive cell therapy forAML.
References
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TL;DR: Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
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TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
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