Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Manipulation of Regulatory Dendritic Cells for Induction Transplantation Tolerance.
TL;DR: In rodent transplantation studies, DCreg-based therapy, by in situ targeting or infusion of ex vivo generated DCregs, exhibits promising potential as a natural, well-tolerated, organ-specific therapeutic strategy for promoting lasting organ- specific transplantation tolerance.
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How to improve photodynamic therapy-induced antitumor immunity for cancer treatment?
TL;DR: This review summarizes the latest progress in the development of strategies to improve the PDT-induced immune effect for enhanced cancer treatment, including tumor microenvironment remodeling, tumor vaccines, subcellular- targeting PDT, and synergistic therapies.
Journal ArticleDOI
Dual Pro- and Anti-Inflammatory Features of Monocyte-Derived Dendritic Cells
Waqas Azeem,Waqas Azeem,Ragnhild Maukon Bakke,Silke Appel,Anne Margrete Øyan,Anne Margrete Øyan,Karl-Henning Kalland,Karl-Henning Kalland +7 more
TL;DR: Genome-wide mRNA expression analyses further underscored the dual development of pro- and anti-inflammatory features of LPS-matured moDCs and suggest a role for β-catenin inhibition in production of more potent therapeutic mo DCs.
Journal ArticleDOI
4-Acetylantroquinonol B from antrodia cinnamomea enhances immune function of dendritic cells against liver cancer stem cells
Ting-Yi Li,Been-Huang Chiang +1 more
TL;DR: 4-AAQB from Antrodia cinnamomea can enhance immune function of dendritic cells against liver cancer stem cells, and may have the potential to be used for liver cancer prevention and immunotherapy.
Journal ArticleDOI
Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect
TL;DR: In this article, the integration of Dendritic cells vaccination with multimodal therapy approaches for cancer treatment paradigms is discussed, and some key questions regarding the integration are addressed.
References
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Shizuo Akira,Kiyoshi Takeda +1 more
TL;DR: Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
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Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
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Neoantigens in cancer immunotherapy
TL;DR: Observations indicate that neoantigen load may form a biomarker in cancer immunotherapy and provide an incentive for the development of novel therapeutic approaches that selectively enhance T cell reactivity against this class of antigens.
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