Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
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Single-cell transfection technologies for cell therapies and gene editing.
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Extracellular‐Vesicle‐Based Drug Delivery Systems for Enhanced Antitumor Therapies through Modulating the Cancer‐Immunity Cycle
TL;DR: This review summarizes the various mechanisms related to affecting the cancer-immunity cycle disorders and briefly discusses the opportunities and challenges of extracellular vesicle-based drug delivery systems in translational clinical applications.
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Cell‐Membrane‐Display Nanotechnology
TL;DR: Details of innovative strategies for displaying cell‐membrane molecules, including the following: displaying molecules of cell membranes on biomaterials, pretreating cell membranes to induce increased expression of inherent molecules ofcell membranes and enhance their function, and inserting additional functional molecules on cell membranes are discussed.
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Emerging glyco-based strategies to steer immune responses.
Marko Anderluh,Francesco Berti,Anna Bzducha-Wróbel,Fabrizio Chiodo,Cinzia Colombo,Federica Compostella,Katarzyna Durlik,Xhenti Ferhati,Rikard Holmdahl,Dragana Jovanovic,Wiesław Kaca,Luigi Lay,Milena Marinović-Cincović,Marco Marradi,Musa Özil,Laura Polito,Josè Juan Reina-Martin,Celso A. Reis,Robert Sackstein,Alba Silipo,Urban Švajger,Ondřej Vaněk,Fumiichiro Yamamoto,Barbara Richichi,Sandra J. van Vliet +24 more
TL;DR: Glycan structures are common posttranslational modifications of proteins, which serve multiple important structural roles (for instance in protein folding), but also are crucial participants in cell-cell communications and in the regulation of immune responses as discussed by the authors.
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Acute aerobic exercise induces a preferential mobilisation of plasmacytoid dendritic cells into the peripheral blood in man.
Frankie F. Brown,John Campbell,Alexander J. Wadley,James P. Fisher,Sarah Aldred,James E. Turner +5 more
TL;DR: Results show that there is a preferential mobilisation of plasmacytoid DCs during exercise, which indicates that exercise may augment immune-surveillance by preferentially mobilising effector cells; these findings have general implications for the promotion of exercise for health, and specifically for the optimisation of DC harvest for cancer immunotherapy.
References
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TL;DR: Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
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Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
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