Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Primary myeloid cell proteomics and transcriptomics: importance of β-tubulin isotypes for osteoclast function.
David Guérit,Pauline Marie,Anne Morel,Justine Maurin,Christel Vérollet,Christel Vérollet,Brigitte Raynaud-Messina,Brigitte Raynaud-Messina,Serge Urbach,Anne Blangy,Anne Blangy +10 more
TL;DR: Analysis of proteomic and transcriptomic data of primary myeloid cells reveals that the β-tubulin isotype Tubb6 participates in osteoclast podosome patterning, sealing zone structure and resorption activity.
Journal ArticleDOI
Elastic Nanovaccine Enhances Dendritic Cell-Mediated Tumor Immunotherapy.
Qiang Li,Zhaogang Teng,Jun Tao,Wenhui Shi,Guangwen Yang,Yu Qing Zhang,Xiao Dan Su,Lin Chen,Weijun Xiu,Lihui Yuwen,Heng Dong,Yongbin Mou +11 more
TL;DR: The elastic effect of the nanovaccine on DC-mediated immune responses is revealed, and the prepared SMONV represents a facile and powerful strategy for antitumor immunotherapy.
Journal ArticleDOI
An Anticancer Drug Cocktail of Three Kinase Inhibitors Improved Response to a Dendritic Cell-Based Cancer Vaccine.
TL;DR: Combination treatment with threeKinase inhibitors are identified as the compounds most effective at modulating moDC immunogenicity, improving anticancer responses from patientderived T cells and in a mouse glioblastoma model.
Journal ArticleDOI
Exosomes as new therapeutic vectors for pancreatic cancer treatment.
Constança Oliveira,João Calmeiro,Mylène A. Carrascal,Amílcar Falcão,Célia Gomes,Bruno Miguel Neves,Maria Teresa Cruz +6 more
TL;DR: This review intends to provide an overview about the scientific and clinical studies regarding the entire process, from isolation and purification of exosomes, to their design and transformation into anti-oncogenic drug delivering systems, particularly to target PC cells.
Journal ArticleDOI
Dendritic cell upregulation of programmed death ligand-1 via DNA demethylation inhibits experimental autoimmune encephalomyelitis
Chia-Bin Chang,Shiao-Pieng Lee,Wei-Ming Chen,Chuang-Ming Wang,Yu-Chun Song,Michael W.Y. Chan,Shu-Fen Wu +6 more
TL;DR: It is concluded that PD-L1 is upregulated via DNA hypomethylation in DCs, resulting in downregulation of autoimmune effector T cell functions, thereby halting progression of EAE.
References
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