Dendritic cell-based immunotherapy
TLDR
What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.Abstract:
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.read more
Citations
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Journal ArticleDOI
Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy.
TL;DR: The biological functions of immune cells within TME and their roles in cancer immunotherapy are reviewed, and the perspectives of the basic studies for improving the effectiveness of the clinical use are discussed.
Journal ArticleDOI
Therapeutic Targeting of the Tumor Microenvironment
TL;DR: A comprehensive analysis of the current therapies targeting the tumor microenvironment (TME) is provided in this paper, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.
Journal ArticleDOI
Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape
TL;DR: It is argued that in various contexts next-generation DC vaccines are ready to meet some challenges currently confronting ICIs, thereby raising the need to integrate DC vaccines in future combinatorial immunotherapy regimens.
Journal ArticleDOI
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer.
TL;DR: The role of the different immune landscapes in CRC and their relationships with defined CRC genetic subtypes are discussed and in which ways CRC cells develop mechanisms to resist ICI are considered.
Journal ArticleDOI
Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source
TL;DR: This review summarized the current knowledge on the application of EVs as DDS from the perspective of different cell origin and weighted the advantages and bottlenecks of EV-based DDS.
References
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Journal ArticleDOI
Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery
Max Schnurr,Qiyuan Chen,Qiyuan Chen,Amanda Shin,Amanda Shin,Weisan Chen,Weisan Chen,Tracey Toy,Tracey Toy,Corinna Jenderek,Corinna Jenderek,Simon Green,Simon Green,Lena Miloradovic,Lena Miloradovic,Debbie Drane,Debbie Drane,Ian D. Davis,Ian D. Davis,Jose A Villadangos,Jose A Villadangos,Ken Shortman,Ken Shortman,Eugene Maraskovsky,Eugene Maraskovsky,Jonathan Cebon,Jonathan Cebon +26 more
TL;DR: The mode of antigen delivery was found to be a determining factor for cytosolic proteolysis by DCs and may provide DCs with ample opportunities for sensitizing tumor-specific T cells against a broad array of tumor antigen epitopes in lymph nodes.
Journal ArticleDOI
Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma
Abhishek D. Garg,Lien Vandenberk,Carolien Koks,Tina Verschuere,Louis Boon,Stefaan Van Gool,Patrizia Agostinis +6 more
TL;DR: It is found that ICD-based DC vaccines improved survival, and that this effect was dependent on the cell-associated reactive oxygen species and release of damage-associated molecular patterns (DAMPs) acting as danger signals, and pending final preclinical checks, I CD-based vaccines can be clinically translated for glioma treatment.
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Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Mireille H. Lahoud,Fatma Ahmet,Susie Kitsoulis,Soo San Wan,David Vremec,Chin-Nien Lee,Belinda Phipson,Wei Shi,Wei Shi,Gordon K. Smyth,Andrew M. Lew,Yu Kato,Scott N. Mueller,Gayle M. Davey,William R. Heath,Ken Shortman,Ken Shortman,Irina Caminschi,Irina Caminschi +18 more
TL;DR: Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells.
Journal ArticleDOI
Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma.
Jacalyn Rosenblatt,Baldev Vasir,Lynne Uhl,Simona Blotta,Claire MacNamara,Poorvi Somaiya,Zekui Wu,Robin Joyce,James D. Levine,Dilani Dombagoda,Yan Emily Yuan,Karen Francoeur,Donna Fitzgerald,Paul G. Richardson,Edie Weller,Kenneth C. Anderson,Donald Kufe,Nikhil C. Munshi,David Avigan +18 more
TL;DR: Vaccination with DC/multiple myeloma fusions was feasible and well tolerated and resulted in antitumor immune responses and disease stabilization in a majority of patients.
Journal ArticleDOI
Plasmacytoid dendritic cells prime IFN‐γ‐secreting melanoma‐specific CD8 lymphocytes and are found in primary melanoma lesions
Mariolina Salio,Marina Cella,William Vermi,Fabio Facchetti,Michael J. Palmowski,Caroline L. Smith,Dawn Shepherd,Marco Colonna,Vincenzo Cerundolo +8 more
TL;DR: A new immunomodulatory role for tissue infiltrating PDC is suggested, which may prime tumor‐specific T cell responses and affect tumor growth via soluble factors.
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