Journal ArticleDOI
Developmental lead acetate exposure induces embryonic toxicity and memory deficit in adult zebrafish.
Jiangfei Chen,Yuanhong Chen,Wei Liu,Chenglian Bai,Xue-Xia Liu,Kai Liu,Rong Li,Jian-Hong Zhu,Changjiang Huang +8 more
TLDR
The results suggested that low dose of developmental lead exposure resulted in embryonic toxicity, behavioral alteration, and adult learning/memory deficit in zebrafish.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2012-11-01. It has received 91 citations till now. The article focuses on the topics: Developmental toxicity & Lead acetate.read more
Citations
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Journal ArticleDOI
A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment.
TL;DR: In this review, the major mechanism associated with toxicities of individual metals was the generation of reactive oxygen species (ROS), and toxicities were expressed through depletion of glutathione and bonding to sulfhydryl groups of proteins.
Journal ArticleDOI
Zebrafish models for assessing developmental and reproductive toxicity
TL;DR: Compared to conventional mammal testing, zebrafish testing for assessing developmental and reproductive toxicity offers several compelling experimental advantages, including transparency of embryo and larva, higher throughput, shorter test period, lower cost, smaller amount of compound required, easier manipulation and direct compound delivery.
Journal ArticleDOI
Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity
Anna Bal-Price,Helena T. Hogberg,Kevin M. Crofton,Mardas Daneshian,Rex E. FitzGerald,Ellen Fritsche,Tuula Heinonen,Susanne Hougaard Bennekou,Stefanie Klima,Aldert H. Piersma,Magdalini Sachana,Timothy J. Shafer,Andrea Terron,Florianne Monnet-Tschudi,Barbara Viviani,Tanja Waldmann,Remco H.S. Westerink,Martin F. Wilks,Hilda Witters,Marie-Gabrielle Zurich,Marcel Leist +20 more
TL;DR: Suggestions are made on how DNT NAMs may be assembled into an integrated approach to testing and assessment (IATA), and a vision is presented on how further NAM development may be guided by knowledge of signaling pathways necessary for brain development, DNT pathophysiology, and relevant adverse outcome pathways (AOP).
Journal ArticleDOI
Effects of ibuprofen, diclofenac and paracetamol on hatch and motor behavior in developing zebrafish (Danio rerio).
TL;DR: It is indicated that ibuprofen and diclofenac significantly affected embryo locomotivity and were potentially neurotoxic, thus posing threats to zebrafish development.
Book ChapterDOI
Arsenic, cadmium and lead
Swaran J.S. Flora,Shruti Agrawal +1 more
TL;DR: The chapter discusses the possible effective treatments such as the role of antioxidants and treatment with an effective chelator against the embryotoxic and teratogenic effects of the three metals/metalloids.
References
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Journal ArticleDOI
Intellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter
Richard L. Canfield,Charles R. Henderson,Deborah A. Cory-Slechta,Christopher Cox,Christopher Cox,Todd A. Jusko,Bruce P. Lanphear +6 more
TL;DR: Blood lead concentrations, even those below 10 microg per deciliter, are inversely associated with children's IQ scores at three and five years of age, and associated declines in IQ are greater at these concentrations than at higher concentrations.
Journal ArticleDOI
Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage
TL;DR: It is suggested that metal-induced oxidative stress in cells can be partially responsible for the toxic effects of heavy metals, suggesting the importance of using antioxidants in heavy metal poisoning.
Journal Article
Lead Toxicity, A Review of the Literature. Part I: Exposure, Evaluation, and Treatment
TL;DR: Data now implicates low-level exposures and blood lead levels previously considered normal as causative factors in cognitive dysfunction, neurobehavioral disorders, neurological damage, hypertension, and renal impairment.
Journal ArticleDOI
Intellectual Impairment in Children With Blood Lead Concentrations Below 10 μg per Deciliter
Richard L. Canfield,Charles R. Henderson,Deborah A. Cory-Slechta,Christopher Cox,Todd A. Jusko,Bruce P. Lanphear +5 more
TL;DR: It is suggested that substantially more children in the United States undergo adverse cognitive change from environmental exposure to lead than was previously thought and primary prevention is essential in view of the lack of effective treatment for children with moderate blood lead elevations.
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