Journal ArticleDOI
Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: a light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study.
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The results suggest that fetal macrophages differentiate from primitive macrophage before the development of promonocytes or monocytes in the mouse yolk sac; they actively proliferate and are colonized into the embryonic tissues.Abstract:
Primitive macrophages first appear in the blood islands of the mouse yolk sac on the ninth day of gestation. After the tenth day of fetal life, these cells differentiate Into fetal macrophages and become mature, with the development of Intracellular organelles. They appear in the mesenchymal layer and further immigrate into the extraembryonic coelom. The fetal macrophages do not show any cytochemical peroxidase or 5’-nucleotldase activity, and they possess a marked proliferative capacity. Promonocytes or monocytes that have an incomplete ultrastructure emerge in the blood islands of the yolk sac a day after the occurrence of the fetal macrophages. These events suggest that fetal macrophages differentiate from primItive macrophages before the development of promonocytes or monocytes in the mouse yolk sac; they actively proliferate and are colonized into the embryonic tissues. These results also Indicate that the ontogeny of the monocyte/macrophage is different in the early embryo compared with its later developmental stages.read more
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Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Daigo Hashimoto,Andrew Chow,Andrew Chow,Clara Noizat,Clara Noizat,Pearline Teo,Mary Beth Beasley,Marylene Leboeuf,Christian Becker,Peter See,Jeremy Price,Daniel Lucas,Melanie Greter,Melanie Greter,Arthur Mortha,Scott W. Boyer,E. Camilla Forsberg,Masato Tanaka,Nico van Rooijen,Adolfo García-Sastre,E. Richard Stanley,Florent Ginhoux,Paul S. Frenette,Miriam Merad +23 more
TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
Journal ArticleDOI
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Elisa Gomez Perdiguero,Kay Klapproth,Christian Schulz,Katrin Busch,Emanuele Azzoni,Lucile Crozet,Hannah Garner,Céline Trouillet,Marella F. T. R. de Bruijn,Frederic Geissmann,Hans Reimer Rodewald +10 more
TL;DR: It is shown in mice that the vast majority of adult tissue-resident macrophages originate from a Tie2+ (also known as Tek) cellular pathway generating Csf1r+ erythro-myeloid progenitors (EMPs) distinct from HSCs.
Journal ArticleDOI
Monocytes and macrophages: developmental pathways and tissue homeostasis
Florent Ginhoux,Steffen Jung +1 more
TL;DR: The evidence that has dramatically changed the authors' understanding of monocyte and macrophage development, and the maintenance of these cells in the steady state is discussed.
Journal ArticleDOI
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Paola Italiani,Diana Boraschi +1 more
TL;DR: This review will address some of the important questions under the general framework of the role of monocytes and macrophages in the initiation, development, resolution, and chronicization of inflammation.
Journal ArticleDOI
Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
Martin Guilliams,Martin Guilliams,Ismé de Kleer,Ismé de Kleer,Sandrine Henri,Sijranke Post,Leen Vanhoutte,Leen Vanhoutte,Sofie De Prijck,Kim Deswarte,Bernard Malissen,Hamida Hammad,Bart N. Lambrecht,Bart N. Lambrecht +13 more
TL;DR: Alveolar macrophages differentiate from fetal monocytes in a GM-CSF–dependent fashion and colonize the alveolar space within a few days after birth.
References
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Journal ArticleDOI
The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.
TL;DR: The early stages of absorption of intravenously injected horseradish peroxidase in proximal tubules of mouse kidney were studied with a new ultrastructural cytochemical technique, which gives sharp localization and is sensitive to protein transport.
Journal ArticleDOI
Periodate-lysine-paraformaldehyde fixative a new fixative for immunoelectron microscopy
Ian W. Mclean,Paul K. Nakane +1 more
TL;DR: Using this fixative and the peroxidase-labeled antibody technique, basement membrane antigen was localized within the cisternae of endoplasmic reticulum of parietal yolk sac cells and in extracellular basement membranes with adequate tissue preservation, a task which has not been successfully accomplished by conventional fixatives.
Journal ArticleDOI
Histochemical methods for acid phosphatase using hexazonium pararosanilin as coupler
Tibor Barka,Paul J. Anderson +1 more
TL;DR: ‘[he use of freslsbv diazotizecl pararosanilin w-itim a-msaphthyb pisosphate its a sinmultaneous coupling azo dye method for acid phosphatase resulted in significant improveumment because of the nmaumy desirable characteristics of the final azo dyed (1, 2).
Journal ArticleDOI
F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Jonathan M. Austyn,Siamon Gordon +1 more
TL;DR: Immunoprecipitation experiments demonstrated that the antigen F4/80 is part of a component of Mr 160000 which is synthesized by the MΦ and, at least in part, exposed on the cell surface.
Journal ArticleDOI
Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo.
TL;DR: The mouse yolk sac has been shown to contain in‐vivo colony forming cells capable of producing granulocytic, megakaryocytic and erythroid spleen colonies, and haemopoietic precursor cells demonstrated in the blood at the time of initiation of the circulation and in the early embryonic liver.
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