Ecology and Evolution as Targets: the Need for Novel Eco-Evo Drugs and Strategies To Fight Antibiotic Resistance
TLDR
This minireview summarizes what is known and what should be further investigated to find drugs and strategies aiming to counteract the “four P's,” penetration, promiscuity, plasticity, and persistence of rapidly spreading bacterial clones, mobile genetic elements, or resistance genes.Abstract:
In recent years, the explosive spread of antibiotic resistance determinants among pathogenic, commensal, and environmental bacteria has reached a global dimension. Classical measures trying to contain or slow locally the progress of antibiotic resistance in patients on the basis of better antibiotic prescribing policies have clearly become insufficient at the global level. Urgent measures are needed to directly confront the processes influencing antibiotic resistance pollution in the microbiosphere. Recent interdisciplinary research indicates that new eco-evo drugs and strategies, which take ecology and evolution into account, have a promising role in resistance prevention, decontamination, and the eventual restoration of antibiotic susceptibility. This minireview summarizes what is known and what should be further investigated to find drugs and strategies aiming to counteract the "four P's," penetration, promiscuity, plasticity, and persistence of rapidly spreading bacterial clones, mobile genetic elements, or resistance genes. The term "drug" is used in this eco-evo perspective as a tool to fight resistance that is able to prevent, cure, or decrease potential damage caused by antibiotic resistance, not necessarily only at the individual level (the patient) but also at the ecological and evolutionary levels. This view offers a wealth of research opportunities for science and technology and also represents a large adaptive challenge for regulatory agencies and public health officers. Eco-evo drugs and interventions constitute a new avenue for research that might influence not only antibiotic resistance but the maintenance of a healthy interaction between humans and microbial systems in a rapidly changing biosphere.read more
Citations
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Tackling antibiotic resistance: the environmental framework
Thomas U. Berendonk,Célia M. Manaia,Christophe Merlin,Despo Fatta-Kassinos,Eddie Cytryn,Fiona Walsh,Helmut Bürgmann,Henning Sørum,Madelaine Norström,Marie-Noëlle Pons,Norbert Kreuzinger,Pentti Huovinen,Stefania Stefani,Thomas Schwartz,Veljo Kisand,Fernando Baquero,José L. Martínez +16 more
TL;DR: The main knowledge gaps, the future research needs and the policy and management options that should be prioritized to tackle antibiotic resistance in the environment are discussed.
Journal ArticleDOI
Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World?
TL;DR: This review considers how bacterial virulence and fitness are affected by antibiotic resistance and also how the relationship between virulent and resistance is affected by different genetic mechanisms and by the most prevalent global responses.
Journal ArticleDOI
Environmental factors influencing the development and spread of antibiotic resistance
TL;DR: This work attempts to define the ecological and evolutionary environmental factors that contribute to resistance development and transmission and investigates under what conditions and to what extent environmental selection for resistance takes place.
Journal ArticleDOI
Defining and combating antibiotic resistance from One Health and Global Health perspectives
TL;DR: This Review provides updated information on the elements involved in the evolution and spread of antibiotic resistance at local and global levels, and proposes studies to be performed and strategies to be followed that may help reduce the burden of antibiotics resistance as well as its impact on human and planetary health.
Journal ArticleDOI
The increasing threat of Pseudomonas aeruginosa high-risk clones.
TL;DR: The population structure, epidemiology, antimicrobial resistance mechanisms and virulence of the P. aeruginosa high-risk clones are reviewed and the aspects related to their detection in the clinical microbiology laboratory and the implications for infection control and public health are discussed.
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