Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
Citations
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Journal ArticleDOI
Technology: DNA has nowhere to hide
TL;DR: Results are striking: by genotyping only 50,000 SNPs, single individuals can be detected even when each one makes up only 0.1% of the sample and the amount of noise only marginally affects accuracy.
Journal ArticleDOI
Population Identifiability from Forensic Genetic Markers: Ancestry Variation in Latin America
TL;DR: The ability of CODIS and CODis-proxy marker panels to accurately estimate admixture proportions of individuals, including a sample of Latinos with a wide range of ancestry proportions, is tested.
Dissertation
Single nucleotide polymorphisms : characterisation and application to profiling of degraded DNA
TL;DR: SNPs produced a higher success rate than STRs when tested with samples obtained from human teeth remains and on samples subjected to DNase 1 digestion, and showed more resistance to degradation than the STRs size ranging between 100 and 360 bp.
Dissertation
Application of autosomal INDELs as a forensic tool in Qatar
TL;DR: The results indicated that 30 autosomal INDELs contained within the Qiagen™ Investigator™ DIPplex kit, although useful for forensic identification, poorly differentiate five population groups of Qatar.
References
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Journal ArticleDOI
Hypervariable 'minisatellite' regions in human DNA.
TL;DR: A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.
Book ChapterDOI
The Apportionment of Human Diversity
TL;DR: Lewontin this article pointed out that even in the present era of Darwinism there is considerable diversity of opinion about the amount or importance of intragroup variation as opposed to the variation between races and species.
Journal ArticleDOI
Individual-specific 'fingerprints' of human DNA.
TL;DR: It is shown that other variant (core)n probes can detect additional sets of hypervariable minisatellites to produce somatically stable DNA ‘fingerprints’ which are completely specific to an individual (or to his or her identical twin) and can be applied directly to problems of human identification, including parenthood testing.