Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
Citations
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Journal ArticleDOI
Genetic diversity, forensic feature, and phylogenetic analysis of Guizhou Tujia population via 19 X-STRs
Li Luo,Hongyan Gao,Lilan Yao,Fei Long,Hao Zhang,Lushun Zhang,Yong Liu,Jian Yu,Limei Yu,Pengyu Chen +9 more
TL;DR: X‐chromosome short tandem repeats with unique sex‐linkage inheritance models play a complementary role in forensic science and some genetic evidence focusing on X‐STRs for various minorities was reported.
Journal ArticleDOI
Population data and forensic efficiency of 21 autosomal STR loci included in AGCU EX22 amplification system in the Wanzhou Han population.
TL;DR: The results in forensic characteristic analyses indicated that the 21 STRs are highly polymorphic and can be served as a useful tool in forensic routine practices and the population comparison indicated that close geographic or ethnic origin groups had a strong genetic affinity with each other.
Posted ContentDOI
The Mutational Dynamics of Short Tandem Repeats in Large, Multigenerational Families
TL;DR: In this paper, the authors used HipSTR to identify de novo short tandem repeat (STR) mutations in the 2nd generation of CEPH pedigrees and estimated the genome-wide pattern of mutations at STR loci.
Journal ArticleDOI
Forensic features and genetic structure of the Hotan Uyghur inferred from 27 forensic markers.
TL;DR: The findings not only reveal that Chinese Uyghur is a homogenous population based on forensic genetic markers, but also indicate that population genetic affinity is closely related to the adjacent populations with common ethnic origin.
Journal ArticleDOI
New Perspectives for Whole Genome Amplification in Forensic STR Analysis
TL;DR: This review article tries to summarize current knowledge about WGA in forensics and suggests the forensic analysis of single-donor bioparticles and of single cells as promising applications.
References
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Journal ArticleDOI
Hypervariable 'minisatellite' regions in human DNA.
TL;DR: A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.
Book ChapterDOI
The Apportionment of Human Diversity
TL;DR: Lewontin this article pointed out that even in the present era of Darwinism there is considerable diversity of opinion about the amount or importance of intragroup variation as opposed to the variation between races and species.
Journal ArticleDOI
Individual-specific 'fingerprints' of human DNA.
TL;DR: It is shown that other variant (core)n probes can detect additional sets of hypervariable minisatellites to produce somatically stable DNA ‘fingerprints’ which are completely specific to an individual (or to his or her identical twin) and can be applied directly to problems of human identification, including parenthood testing.