Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
Citations
More filters
Journal ArticleDOI
Modular-Based Integrated Microsystem with Multiple Sample Preparation Modules for Automated Forensic DNA Typing from Reference to Challenging Samples.
TL;DR: It is demonstrated that minute amounts of blood, highly diluted blood, and latent bloodstains can be automatically analyzed using the fully integrated microsystem, reliably producing full STR profiles with a 100% calling of all the alleles.
Book ChapterDOI
Forensic Typing of Single Cells Using Droplet Microfluidics
Tao Geng,Richard A. Mathies +1 more
TL;DR: A droplet microfluidics-based technology for single-cell STR typing with high sensitivity, throughput, and fidelity, effective in preserving single-genome integrity when analyzing diverse cellular materials yet insensitive to background DNA contamination.
Journal ArticleDOI
Accurate profiling of forensic autosomal STRs using the Oxford Nanopore Technologies MinION device.
Courtney L. Hall,Rupesh K. Kesharwani,Nicole Phillips,John V. Planz,Fritz J. Sedlazeck,Roxanne R. Zascavage,Roxanne R. Zascavage +6 more
TL;DR: In this paper, the authors used the Oxford Nanopore Technologies (ONT) MinION device to generate length-and sequence-based profiles of short tandem repeat (STR) markers.
Journal Article
Tackling Technical Debt: Managing Advances in DNA Technology That Outpace the Evolution of Law
TL;DR: The use of DNA in criminal investigations has been a hot topic in the last few decades as mentioned in this paper, with a high rate of return on DNA-based investment almost dictates this result: As of December 2015, CODIS has produced over 315,410 hits that assisted in at least 303,201 investigations.
Dissertation
Does police culture prevent the New Zealand Police from making the best use of DNA technology to investigate crime
TL;DR: The New Zealand National DNA Databank has been used by the New Zealand Police to collect DNA data as discussed by the authors, which is used to identify an offender in New Zealand's criminal justice system.
References
More filters
Journal ArticleDOI
Hypervariable 'minisatellite' regions in human DNA.
TL;DR: A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.
Book ChapterDOI
The Apportionment of Human Diversity
TL;DR: Lewontin this article pointed out that even in the present era of Darwinism there is considerable diversity of opinion about the amount or importance of intragroup variation as opposed to the variation between races and species.
Journal ArticleDOI
Individual-specific 'fingerprints' of human DNA.
TL;DR: It is shown that other variant (core)n probes can detect additional sets of hypervariable minisatellites to produce somatically stable DNA ‘fingerprints’ which are completely specific to an individual (or to his or her identical twin) and can be applied directly to problems of human identification, including parenthood testing.