Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
Citations
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Journal ArticleDOI
Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.
Nils Homer,Nils Homer,Szabolcs Szelinger,Margot Redman,David Duggan,Waibhav Tembe,Jill Muehling,John V. Pearson,Dietrich A. Stephan,Stanley F. Nelson,David Craig +10 more
TL;DR: High-density single nucleotide polymorphism genotyping microarrays are used to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture, and suggest future research efforts into assessing the viability of previously sub-optimal DNA sources due to sample contamination.
Journal ArticleDOI
Jasmonate passes muster: a receptor and targets for the defense hormone.
TL;DR: The oxylipin jasmonate (JA) regulates many aspects of growth, development, and environmental responses in plants, particularly defense responses against herbivores and necrotrophic pathogens as mentioned in this paper.
Journal ArticleDOI
Genetics and genomics of core short tandem repeat loci used in human identity testing.
TL;DR: The physical location of each STR locus in the human genome is delineated and allele ranges and variants observed in human populations are summarized as are mutation rates observed from parentage testing.
Journal ArticleDOI
Improving human forensics through advances in genetics, genomics and molecular biology
Manfred Kayser,Peter de Knijff +1 more
TL;DR: Advances in genetics, genomics and molecular biology are likely to improve human forensic case work in the near future, including new molecular approaches for finding individuals previously unknown to investigators, and new molecular methods to support links between forensic sample donors and criminal acts.
Journal ArticleDOI
Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application.
TL;DR: This review examines the advances in paper-based microfluidic diagnostics for medical diagnosis in the context of global health from 2007 to 2016 and highlights emerging health applications, such as male fertility testing and wearable diagnostics.
References
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Book
Forensic DNA typing : biology & technology behind STR markers
TL;DR: This book discusses DNA Testing in High-Profile Cases, Laboratory Validation, and Suppliers of DNA Analysis Equipment, Products, or Services Index.
Journal ArticleDOI
Interpreting DNA mixtures
Bruce S. Weir,Christopher M. Triggs,L. Starling,L. I. Stowell,Kevan A. J. Walsh,John Buckleton +5 more
TL;DR: The interpretation of mixed DNA stains is explained in the context of likelihood ratios, and includes the "2p" modification suggested by the 1996 NRC report.
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A multiplex allele-specific primer extension assay for forensically informative SNPs distributed throughout the mitochondrial genome
TL;DR: A set of 11 SNPs selected for distinguishing individuals of the most common Caucasian HV1/HV2 mitotype were incorporated in an allele specific primer extension assay that performs well for heteroplasmy and mixture detection, and for typical mtDNA casework samples with highly degraded DNA.
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Mitochondrial DNA regions HVI and HVII population data.
Bruce Budowle,Mark R. Wilson,Joseph A. DiZinno,Clinton Stauffer,Michael A. Fasano,Mitchell M. Holland,Keith L. Monson +6 more
TL;DR: Differences between major population groups (i.e., between African, Caucasian, and Asian) are quite evident, and similar ethnic population groups carried similar SSO polymorphism frequencies, and there were only a few SSO types that showed significant differences between subpopulation groups.
Journal ArticleDOI
Is the amelogenin gene reliable for gender identification in forensic casework and prenatal diagnosis
TL;DR: This study showed a deletion of Y chromosome-specific amelogenin in five Indian males, who are proposed to call “deleted-amelogenin males” (DAMs), who but for the detection of the presence of other Y-specific markers would have been identified as females.