Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
Citations
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Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.
Nils Homer,Nils Homer,Szabolcs Szelinger,Margot Redman,David Duggan,Waibhav Tembe,Jill Muehling,John V. Pearson,Dietrich A. Stephan,Stanley F. Nelson,David Craig +10 more
TL;DR: High-density single nucleotide polymorphism genotyping microarrays are used to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture, and suggest future research efforts into assessing the viability of previously sub-optimal DNA sources due to sample contamination.
Journal ArticleDOI
Jasmonate passes muster: a receptor and targets for the defense hormone.
TL;DR: The oxylipin jasmonate (JA) regulates many aspects of growth, development, and environmental responses in plants, particularly defense responses against herbivores and necrotrophic pathogens as mentioned in this paper.
Journal ArticleDOI
Genetics and genomics of core short tandem repeat loci used in human identity testing.
TL;DR: The physical location of each STR locus in the human genome is delineated and allele ranges and variants observed in human populations are summarized as are mutation rates observed from parentage testing.
Journal ArticleDOI
Improving human forensics through advances in genetics, genomics and molecular biology
Manfred Kayser,Peter de Knijff +1 more
TL;DR: Advances in genetics, genomics and molecular biology are likely to improve human forensic case work in the near future, including new molecular approaches for finding individuals previously unknown to investigators, and new molecular methods to support links between forensic sample donors and criminal acts.
Journal ArticleDOI
Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application.
TL;DR: This review examines the advances in paper-based microfluidic diagnostics for medical diagnosis in the context of global health from 2007 to 2016 and highlights emerging health applications, such as male fertility testing and wearable diagnostics.
References
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Journal ArticleDOI
Establishing the identity of Anna Anderson Manahan
Peter Gill,C. P. Kimpton,R. Aliston-Greiner,Kevin Sullivan,Mark Stoneking,Terry Melton,J. Nott,S Barritt,Rhonda K. Roby,Mitchell M. Holland +9 more
Journal ArticleDOI
An extremely sensitive species-specific ARMs PCR test for the presence of tiger bone DNA (vol 126, pg 137, 2002)
TL;DR: A highly sensitive tiger-specific real-time PCR assay has been developed providing a rapid and highly sensitive forensic test for species of origin and potential applications to the monitoring of wild populations are demonstrated by the successful identification of shed hairs and faecal samples.
Journal Article
Application of forensic DNA testing in the legal system
TL;DR: In this article, the authors present background information on DNA, human genetics, and the application of DNA analysis to legal problems, as well as the commonly applied respective mathematics, and they believe that in the near future this technology will be generally accepted in the legal system.
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Whole genome amplification—the solution for a common problem in forensic casework?
Peter M. Schneider,Kinga Balogh,N. Naveran,Magdalena Bogus,Klaus Bender,M. V. Lareu,Angel Carracedo +6 more
TL;DR: To assess the quality of amplified DNA obtained by whole genome amplification, 17 independent STR loci have been typed using two multiplex kits and results have been compared for correct genotypes, heterozygous peak balance and allelic dropout.
Journal ArticleDOI
DNA fingerprinting of mosses.
TL;DR: It was concluded that B. albicans found on the suspects was likely to originate from the crime scene and that the sample of C. lindbergii may also have originated from the same site.