Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
Citations
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Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.
Nils Homer,Nils Homer,Szabolcs Szelinger,Margot Redman,David Duggan,Waibhav Tembe,Jill Muehling,John V. Pearson,Dietrich A. Stephan,Stanley F. Nelson,David Craig +10 more
TL;DR: High-density single nucleotide polymorphism genotyping microarrays are used to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture, and suggest future research efforts into assessing the viability of previously sub-optimal DNA sources due to sample contamination.
Journal ArticleDOI
Jasmonate passes muster: a receptor and targets for the defense hormone.
TL;DR: The oxylipin jasmonate (JA) regulates many aspects of growth, development, and environmental responses in plants, particularly defense responses against herbivores and necrotrophic pathogens as mentioned in this paper.
Journal ArticleDOI
Genetics and genomics of core short tandem repeat loci used in human identity testing.
TL;DR: The physical location of each STR locus in the human genome is delineated and allele ranges and variants observed in human populations are summarized as are mutation rates observed from parentage testing.
Journal ArticleDOI
Improving human forensics through advances in genetics, genomics and molecular biology
Manfred Kayser,Peter de Knijff +1 more
TL;DR: Advances in genetics, genomics and molecular biology are likely to improve human forensic case work in the near future, including new molecular approaches for finding individuals previously unknown to investigators, and new molecular methods to support links between forensic sample donors and criminal acts.
Journal ArticleDOI
Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application.
TL;DR: This review examines the advances in paper-based microfluidic diagnostics for medical diagnosis in the context of global health from 2007 to 2016 and highlights emerging health applications, such as male fertility testing and wearable diagnostics.
References
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Journal ArticleDOI
An assessment of the utility of single nucleotide polymorphisms (SNPs) for forensic purposes.
TL;DR: It is demonstrated that relatively small arrays of approx.
Journal ArticleDOI
Messenger RNA profiling: a prototype method to supplant conventional methods for body fluid identification.
Jane Juusola,Jack Ballantyne +1 more
TL;DR: It is demonstrated that RNA is stable in biological stains and can be recovered in sufficient quantity and quality for analysis, and constitutes the basis of a prototype RNA based assay system that may eventually supplant conventional methods for body fluid identification.
Journal ArticleDOI
The Distribution of the Human Blood Groups and other Polymorphisms.
TL;DR: The blood groups have been a trail blazer for the study of human polymorphism, and this book provides a data bank in a single volume which can be consulted at short notice in most larger laboratories.
Journal ArticleDOI
Online reference database of European Y-chromosomal short tandem repeat (STR) haplotypes
Lutz Roewer,Michael Krawczak,Sascha Willuweit,M. Nagy,Célia Alves,António Amorim,Katja Anslinger,Christa Augustin,A. Betz,Elena Bosch,Alessandra Caglià,Angel Carracedo,Daniel Corach,A.-F. Dekairelle,T. Dobosz,B.M. Dupuy,S. Füredi,Christian Gehrig,Leonor Gusmão,Jürgen Henke,Lotte Henke,M. Hidding,Carsten Hohoff,Bernadette Hoste,Mark A. Jobling,H.J. Kärgel,P. de Knijff,Rüdiger Lessig,E. Liebeherr,Miguel Lorente,Begoña Martínez-Jarreta,P. Nievas,Magdalena Nowak,Walther Parson,Vincenzo Lorenzo Pascali,Gustavo Penacino,Rafał Płoski,Burkhard Rolf,Andrea Sala,C. Schmitt,Ulrike Schmidt,Peter M. Schneider,Reinhard Szibor,J. Teifel-Greding,Manfred Kayser +44 more
TL;DR: The reference database of highly informative Y-chromosomal short tandem repeat (STR) haplotypes (YHRD), available online at http://ystr.charite.de, represents the largest collection of male-specific genetic profiles currently available for European populations.
Journal ArticleDOI
Validation of short tandem repeats (STRs) for forensic usage: performance testing of fluorescent multiplex STR systems and analysis of authentic and simulated forensic samples.
Tamyra R. Moretti,Anne L. Baumstark,Debra A. Defenbaugh,Kathleen M. Keys,Jill B. Smerick,Bruce Budowle +5 more
TL;DR: The data demonstrate that the commercially available multiplex kits can be used to amplify and type STR loci successfully from DNA derived from human biological specimens.