Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
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Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.
Nils Homer,Nils Homer,Szabolcs Szelinger,Margot Redman,David Duggan,Waibhav Tembe,Jill Muehling,John V. Pearson,Dietrich A. Stephan,Stanley F. Nelson,David Craig +10 more
TL;DR: High-density single nucleotide polymorphism genotyping microarrays are used to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture, and suggest future research efforts into assessing the viability of previously sub-optimal DNA sources due to sample contamination.
Journal ArticleDOI
Jasmonate passes muster: a receptor and targets for the defense hormone.
TL;DR: The oxylipin jasmonate (JA) regulates many aspects of growth, development, and environmental responses in plants, particularly defense responses against herbivores and necrotrophic pathogens as mentioned in this paper.
Journal ArticleDOI
Genetics and genomics of core short tandem repeat loci used in human identity testing.
TL;DR: The physical location of each STR locus in the human genome is delineated and allele ranges and variants observed in human populations are summarized as are mutation rates observed from parentage testing.
Journal ArticleDOI
Improving human forensics through advances in genetics, genomics and molecular biology
Manfred Kayser,Peter de Knijff +1 more
TL;DR: Advances in genetics, genomics and molecular biology are likely to improve human forensic case work in the near future, including new molecular approaches for finding individuals previously unknown to investigators, and new molecular methods to support links between forensic sample donors and criminal acts.
Journal ArticleDOI
Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application.
TL;DR: This review examines the advances in paper-based microfluidic diagnostics for medical diagnosis in the context of global health from 2007 to 2016 and highlights emerging health applications, such as male fertility testing and wearable diagnostics.
References
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Journal ArticleDOI
A Comprehensive Survey of Human Y-Chromosomal Microsatellites
Manfred Kayser,Ralf Kittler,Axel Erler,Minttu Hedman,Andrew C. Lee,Aisha Mohyuddin,S. Qasim Mehdi,Zoë H. Rosser,Mark Stoneking,Mark A. Jobling,Antti Sajantila,Chris Tyler-Smith,Chris Tyler-Smith +12 more
TL;DR: A large number of new, highly polymorphic Y-chromosomal microsatellites are now available for population-genetic, evolutionary, genealogical, and forensic investigations.
Journal ArticleDOI
Microfluidic devices for DNA sequencing: sample preparation and electrophoretic analysis.
TL;DR: In this paper, a microfabricated device for high-throughput DNA sequencing that couples clone isolation, template amplification, Sanger extension, purification, and electrophoretic analysis in a single microfluidic circuit is presented.
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Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians
Michael D. Coble,Michael D. Coble,Rebecca S. Just,Jennifer E. O'Callaghan,Ilona H. Letmanyi,Christine Tara Peterson,Jodi A. Irwin,Thomas J. Parsons +7 more
TL;DR: It is found that over the entire mtGenome even individuals with the same HV1/HV2 type rarely match, and the 18 common types the authors analyzed are resolved to 105 different types, 55 of which are seen only once.
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Genetic ancestry and the search for personalized genetic histories.
Mark D. Shriver,Rick A. Kittles +1 more
TL;DR: This paper presents a meta-analyses of eight major databases of genetic information across human populations that show clear trends in the growth and development of genetic ancestry testing in the United States.
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